GO Annotations Graph

• Symbol: Plscr1
• Name: phospholipid scramblase 1
• ID: MGI:893575

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0042609	CD4 receptor binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0032791	lead ion binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0045340	mercury ion binding	ISO	J:164563
Molecular Function	GO:0004518	nuclease activity	ISO	J:164563
Molecular Function	GO:0017128	phospholipid scramblase activity	ISO	J:164563
Molecular Function	GO:0017128	phospholipid scramblase activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:292529
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0001618	virus receptor activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:127023
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:127023
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:175205
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0006953	acute-phase response	IEP	J:127023
Biological Process	GO:0071345	cellular response to cytokine stimulus	IEP	J:127023
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IEP	J:127023
Biological Process	GO:0051607	defense response to virus	IMP	J:175192
Biological Process	GO:0006955	immune response	ISO	J:155856
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IDA	J:182395
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:92404
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:108434
Biological Process	GO:0045071	negative regulation of viral genome replication	IMP	J:175192
Biological Process	GO:0006659	phosphatidylserine biosynthetic process	IDA	J:175205
Biological Process	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	IMP	J:292529
Biological Process	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	IBA	J:265628
Biological Process	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	IDA	J:175205
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	ISO	J:155856
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	IDA	J:175205
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:108434
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:175192
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA	J:175205
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	ISO	J:155856
Biological Process	GO:0033003	regulation of mast cell activation	ISO	J:155856
Biological Process	GO:0035455	response to interferon-alpha	IMP	J:175192