GO Annotations Graph

• Symbol: Ager
• Name: advanced glycosylation end product-specific receptor
• ID: MGI:893592

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0070379	high mobility group box 1 binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005055	laminin receptor activity	IBA	J:265628
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:263374
Molecular Function	GO:0005515	protein binding	IPI	J:154746
Molecular Function	GO:0005515	protein binding	IPI	J:55874
Molecular Function	GO:0005515	protein binding	IPI	J:168000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0044548	S100 protein binding	ISO	J:155856
Molecular Function	GO:0044548	S100 protein binding	ISO	J:164563
Molecular Function	GO:0044548	S100 protein binding	IPI	J:159134
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0048143	astrocyte activation	ISO	J:164563
Biological Process	GO:0014002	astrocyte development	IMP	J:188377
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:155856
Biological Process	GO:1904646	cellular response to amyloid-beta	IMP	J:255329
Biological Process	GO:0010255	glucose mediated signaling pathway	ISO	J:164563
Biological Process	GO:0050930	induction of positive chemotaxis	IMP	J:88808
Biological Process	GO:0006954	inflammatory response	IGI	J:168000
Biological Process	GO:0006954	inflammatory response	IGI	J:168000
Biological Process	GO:0007611	learning or memory	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	IGI	J:184555
Biological Process	GO:0001774	microglial cell activation	ISO	J:164563
Biological Process	GO:1903523	negative regulation of blood circulation	IGI	J:268022
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0010596	negative regulation of endothelial cell migration	ISO	J:155856
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	ISO	J:164563
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	IGI	J:248440
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0032722	positive regulation of chemokine production	IGI	J:184555
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:155856
Biological Process	GO:1904472	positive regulation of endothelin production	IGI	J:268022
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:184555
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:184555
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:149031
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	IGI	J:215451
Biological Process	GO:2000439	positive regulation of monocyte extravasation	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:155856
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:184555
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	ISO	J:155856
Biological Process	GO:0072657	protein localization to membrane	IMP	J:149031
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	ISO	J:164563
Biological Process	GO:0051101	regulation of DNA binding	IMP	J:149031
Biological Process	GO:0050727	regulation of inflammatory response	IDA	J:55874
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	IMP	J:255329
Biological Process	GO:1900744	regulation of p38MAPK cascade	IGI	J:248440
Biological Process	GO:1900744	regulation of p38MAPK cascade	IBA	J:265628
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	ISO	J:164563
Biological Process	GO:0001914	regulation of T cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:1904645	response to amyloid-beta	IGI	J:248440
Biological Process	GO:0001666	response to hypoxia	IMP	J:149031
Biological Process	GO:0045056	transcytosis	IGI	J:184555
Biological Process	GO:0045056	transcytosis	IMP	J:268022
Biological Process	GO:0150104	transport across blood-brain barrier	ISO	J:164563