GO Annotations Graph

• Symbol: Sh2b3
• Name: SH2B adaptor protein 3
• ID: MGI:893598

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042301	phosphate ion binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:76219
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:89937
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0035591	signaling adaptor activity	IEA	J:72247
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	IPI	J:89937
Molecular Function	GO:0005173	stem cell factor receptor binding	IDA	J:89937
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:1990869	cellular response to chemokine	IMP	J:93918
Biological Process	GO:0036016	cellular response to interleukin-3	IDA	J:93918
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:89937
Biological Process	GO:0035162	embryonic hemopoiesis	IDA	J:89937
Biological Process	GO:0048821	erythrocyte development	ISO	J:164563
Biological Process	GO:0060218	hematopoietic stem cell differentiation	IMP	J:89937
Biological Process	GO:0030097	hemopoiesis	IMP	J:76219
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:76219
Biological Process	GO:0035855	megakaryocyte development	IMP	J:93918
Biological Process	GO:0035702	monocyte homeostasis	IGI	J:242558
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:93918
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	IMP	J:93918
Biological Process	GO:1900235	negative regulation of Kit signaling pathway	IMP	J:89937
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:93918
Biological Process	GO:0090331	negative regulation of platelet aggregation	IGI	J:242558
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IDA	J:93918
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:155856
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	IMP	J:93918
Biological Process	GO:0001780	neutrophil homeostasis	IGI	J:242558
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	IGI	J:242558
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	IMP	J:93918