Smad4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:96056
Molecular Function	GO:0003682	chromatin binding	IDA	J:136812
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:93586
Molecular Function	GO:0003677	DNA binding	IDA	J:80201
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:150686
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IGI	J:170471
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:85559
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:107396
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:86912
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0031005	filamin binding	ISO	J:155856
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:183041
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:283183
Molecular Function	GO:0005515	protein binding	IPI	J:143960
Molecular Function	GO:0005515	protein binding	IPI	J:180221
Molecular Function	GO:0005515	protein binding	IPI	J:169049
Molecular Function	GO:0005515	protein binding	IPI	J:182366
Molecular Function	GO:0005515	protein binding	IPI	J:245319
Molecular Function	GO:0005515	protein binding	IPI	J:200480
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0005515	protein binding	IPI	J:86912
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0005515	protein binding	IPI	J:106894
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0005515	protein binding	IPI	J:81747
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:89598
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IGI	J:170471
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:183041
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:170471
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0043199	sulfate binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Cellular Component	GO:0032444	activin responsive factor complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:87103
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9717136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754488
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756720
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756964
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9625492
Cellular Component	GO:0005634	nucleus	IDA	J:87103
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:142136
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:150686
Cellular Component	GO:0071141	SMAD protein complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:116368
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:92066
Biological Process	GO:0036302	atrioventricular canal development	IGI	J:170471
Biological Process	GO:0003190	atrioventricular valve formation	IGI	J:170471
Biological Process	GO:0007411	axon guidance	IMP	J:169302
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:129666
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0003360	brainstem development	IMP	J:169302
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IGI	J:99651
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IGI	J:99651
Biological Process	GO:0003279	cardiac septum development	IGI	J:170471
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IGI	J:67459
Biological Process	GO:0008283	cell population proliferation	IGI	J:46242
Biological Process	GO:0008283	cell population proliferation	IGI	J:59214
Biological Process	GO:0008283	cell population proliferation	IGI	J:99651
Biological Process	GO:0008283	cell population proliferation	IGI	J:99651
Biological Process	GO:0008283	cell population proliferation	IGI	J:46242
Biological Process	GO:0008283	cell population proliferation	IMP	J:45399
Biological Process	GO:0008283	cell population proliferation	IGI	J:59214
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0048589	developmental growth	IMP	J:45399
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:164563
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:189073
Biological Process	GO:0060956	endocardial cell differentiation	IMP	J:170471
Biological Process	GO:0007492	endoderm development	IMP	J:45399
Biological Process	GO:0042118	endothelial cell activation	IMP	J:170471
Biological Process	GO:0010631	epithelial cell migration	ISO	J:164563
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:170471
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0008585	female gonad development	IGI	J:214944
Biological Process	GO:0061040	female gonad morphogenesis	IMP	J:214944
Biological Process	GO:0048859	formation of anatomical boundary	IMP	J:45399
Biological Process	GO:0007369	gastrulation	IMP	J:45399
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:92066
Biological Process	GO:0001701	in utero embryonic development	IMP	J:45399
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:129666
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:129666
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0001822	kidney development	IMP	J:108109
Biological Process	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	IMP	J:114629
Biological Process	GO:0008584	male gonad development	IMP	J:214944
Biological Process	GO:0007498	mesoderm development	IMP	J:45399
Biological Process	GO:0072133	metanephric mesenchyme morphogenesis	IMP	J:108109
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	IMP	J:114629
Biological Process	GO:1905305	negative regulation of cardiac myofibril assembly	IMP	J:114629
Biological Process	GO:0060548	negative regulation of cell death	IMP	J:108109
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:46242
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:67459
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:99651
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:99651
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:59214
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:114629
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:139214
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:129666
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:114629
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:214944
Biological Process	GO:0072134	nephrogenic mesenchyme morphogenesis	IMP	J:108109
Biological Process	GO:0014033	neural crest cell differentiation	IMP	J:153961
Biological Process	GO:0048663	neuron fate commitment	IMP	J:126770
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:155856
Biological Process	GO:0003148	outflow tract septum morphogenesis	IGI	J:124260
Biological Process	GO:0001541	ovarian follicle development	IGI	J:214944
Biological Process	GO:0001541	ovarian follicle development	IMP	J:214944
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	IMP	J:170471
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:94649
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:87103
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	IGI	J:214944
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	IMP	J:214944
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	IMP	J:129666
Biological Process	GO:2000617	positive regulation of histone H3-K9 acetylation	IMP	J:129666
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	IGI	J:214944
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	IMP	J:214944
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:248460
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:87103
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	IMP	J:87103
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:129666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:170471
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:150686
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:139214
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107396
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:214944
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:142136
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:48930
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:146013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:149852
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:214944
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051098	regulation of binding	IDA	J:94649
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:61211
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74003
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74003
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:61211
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:74003
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0051797	regulation of hair follicle development	IMP	J:142136
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:80201
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032909	regulation of transforming growth factor beta2 production	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0071559	response to transforming growth factor beta	ISO	J:164563
Biological Process	GO:0048733	sebaceous gland development	IMP	J:142136
Biological Process	GO:0062009	secondary palate development	IMP	J:87103
Biological Process	GO:0072520	seminiferous tubule development	IMP	J:214944
Biological Process	GO:0007338	single fertilization	IGI	J:214944
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0032525	somite rostral/caudal axis specification	IMP	J:45399
Biological Process	GO:0007283	spermatogenesis	IMP	J:214944
Biological Process	GO:0048729	tissue morphogenesis	IMP	J:45399
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:142136
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:129666
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0060065	uterus development	IGI	J:214944
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:114629
Biological Process	GO:0042060	wound healing	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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