GO Annotations Graph

• Symbol: Crhr2
• Name: corticotropin releasing hormone receptor 2
• ID: MGI:894312

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IBA	J:265628
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IDA	J:76864
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IDA	J:95540
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	ISO	J:155856
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	IBA	J:265628
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	IDA	J:95540
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0017046	peptide hormone binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:95540
Molecular Function	GO:0005515	protein binding	IPI	J:95540
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	IBA	J:265628
Cellular Component	GO:0070852	cell body fiber	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0043196	varicosity	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	ISO	J:155856
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0042423	catecholamine biosynthetic process	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0030855	epithelial cell differentiation	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:95540
Biological Process	GO:0035482	gastric motility	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:76864
Biological Process	GO:0090281	negative regulation of calcium ion import	ISO	J:155856
Biological Process	GO:2000293	negative regulation of defecation	ISO	J:155856
Biological Process	GO:0032811	negative regulation of epinephrine secretion	ISO	J:155856
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:0046882	negative regulation of follicle-stimulating hormone secretion	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0033685	negative regulation of luteinizing hormone secretion	ISO	J:155856
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0014064	positive regulation of serotonin secretion	ISO	J:155856
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0048630	skeletal muscle tissue growth	ISO	J:155856