GO Annotations Graph

• Symbol: Hlcs
• Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
• ID: MGI:894646

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0009374	biotin binding	ISO	J:164563
Molecular Function	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	IBA	J:265628
Molecular Function	GO:0004078	biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity	IEA	J:72245
Molecular Function	GO:0004079	biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity	IEA	J:72245
Molecular Function	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	ISO	J:164563
Molecular Function	GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	ISO	J:155856
Molecular Function	GO:0018271	biotin-protein ligase activity	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0016874	ligase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005652	nuclear lamina	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043687	post-translational protein modification	ISO	J:164563
Biological Process	GO:0036211	protein modification process	IEA	J:72247
Biological Process	GO:0070781	response to biotin	ISO	J:164563