Aurka GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Aurka
aurora kinase A
MGI:894678

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0035175	histone H3S10 kinase activity	IMP	J:169782
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:97428
Molecular Function	GO:0005515	protein binding	IPI	J:158132
Molecular Function	GO:0005515	protein binding	IPI	J:158132
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:73065
Molecular Function	GO:0004672	protein kinase activity	IDA	J:144769
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:97428
Cellular Component	GO:0043203	axon hillock	IDA	J:158132
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:73065
Cellular Component	GO:0005813	centrosome	IDA	J:144769
Cellular Component	GO:0032133	chromosome passenger complex	IBA	J:265628
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-4655356
Cellular Component	GO:0042585	germinal vesicle	IDA	J:91037
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326729
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326729
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326729
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326729
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326729
Cellular Component	GO:0000776	kinetochore	IBA	J:265628
Cellular Component	GO:0072687	meiotic spindle	IDA	J:91037
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005815	microtubule organizing center	IDA	J:319955
Cellular Component	GO:0005815	microtubule organizing center	IGI	J:158132
Cellular Component	GO:0005815	microtubule organizing center	IGI	J:158132
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0072686	mitotic spindle	IDA	J:144769
Cellular Component	GO:0097431	mitotic spindle pole	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-4655356
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0014069	postsynaptic density	IEP	J:326729
Cellular Component	GO:0014069	postsynaptic density	IDA	J:326729
Cellular Component	GO:0014069	postsynaptic density	IDA	J:326729
Cellular Component	GO:0014069	postsynaptic density	IDA	J:326729
Cellular Component	GO:0014069	postsynaptic density	IDA	J:326729
Cellular Component	GO:0045120	pronucleus	IDA	J:91037
Cellular Component	GO:0005819	spindle	ISO	J:155856
Cellular Component	GO:0005876	spindle microtubule	ISO	J:164563
Cellular Component	GO:0005876	spindle microtubule	IBA	J:265628
Cellular Component	GO:0051233	spindle midzone	IBA	J:265628
Cellular Component	GO:0000922	spindle pole	IDA	J:319955
Cellular Component	GO:0031616	spindle pole centrosome	ISO	J:164563
Cellular Component	GO:0031616	spindle pole centrosome	IBA	J:265628
Biological Process	GO:0009948	anterior/posterior axis specification	IMP	J:190555
Biological Process	GO:0006915	apoptotic process	IMP	J:190555
Biological Process	GO:0006915	apoptotic process	IMP	J:190555
Biological Process	GO:0006915	apoptotic process	IMP	J:190555
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0007098	centrosome cycle	IGI	J:117672
Biological Process	GO:0051642	centrosome localization	IMP	J:196491
Biological Process	GO:0061523	cilium disassembly	ISO	J:164563
Biological Process	GO:0097421	liver regeneration	ISO	J:205247
Biological Process	GO:0051321	meiotic cell cycle	IMP	J:169782
Biological Process	GO:0000212	meiotic spindle organization	IMP	J:91037
Biological Process	GO:0000226	microtubule cytoskeleton organization	IGI	J:158132
Biological Process	GO:0000226	microtubule cytoskeleton organization	IGI	J:158132
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:196491
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:97428
Biological Process	GO:0007100	mitotic centrosome separation	IMP	J:145744
Biological Process	GO:0007100	mitotic centrosome separation	IGI	J:117672
Biological Process	GO:0007100	mitotic centrosome separation	IMP	J:145744
Biological Process	GO:0007052	mitotic spindle organization	IBA	J:265628
Biological Process	GO:0007052	mitotic spindle organization	IMP	J:143099
Biological Process	GO:0007052	mitotic spindle organization	IMP	J:198479
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:190555
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0090233	negative regulation of spindle checkpoint	IMP	J:145744
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:1990138	neuron projection extension	IGI	J:158132
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:1900195	positive regulation of oocyte maturation	IMP	J:91037
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:117672
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:117672
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:117672
Biological Process	GO:0071539	protein localization to centrosome	IMP	J:117672
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:73065
Biological Process	GO:0006468	protein phosphorylation	IGI	J:117672
Biological Process	GO:0032465	regulation of cytokinesis	IBA	J:265628
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0009611	response to wounding	ISO	J:205247
Biological Process	GO:0007057	spindle assembly involved in female meiosis I	IMP	J:169782
Biological Process	GO:0007051	spindle organization	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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