GO Annotations Graph

• Symbol: Defa1
• Name: defensin, alpha 1
• ID: MGI:94880

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140911	pore-forming activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:118036
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	IBA	J:265628
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IGI	J:118036
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IGI	J:118036
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IGI	J:118036
Biological Process	GO:0006952	defense response	IEA	J:72247
Biological Process	GO:0006952	defense response	IEA	J:60000
Biological Process	GO:0042742	defense response to bacterium	IDA	J:21032
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IBA	J:265628
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IGI	J:118038
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IGI	J:118038
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IGI	J:118038
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:118036
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:118036
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:118036
Biological Process	GO:0051673	disruption of membrane integrity in another organism	IBA	J:265628
Biological Process	GO:0002227	innate immune response in mucosa	IBA	J:265628
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:118036