GO Annotations Graph

• Symbol: Dhfr
• Name: dihydrofolate reductase
• ID: MGI:94890

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004146	dihydrofolate reductase activity	ISO	J:164563
Molecular Function	GO:0004146	dihydrofolate reductase activity	ISO	J:164563
Molecular Function	GO:0004146	dihydrofolate reductase activity	IDA	J:223303
Molecular Function	GO:0004146	dihydrofolate reductase activity	ISO	J:155856
Molecular Function	GO:0004146	dihydrofolate reductase activity	IBA	J:265628
Molecular Function	GO:0004146	dihydrofolate reductase activity	IDA	J:19257
Molecular Function	GO:0004146	dihydrofolate reductase activity	IDA	J:19257
Molecular Function	GO:0004146	dihydrofolate reductase activity	IDA	J:87848
Molecular Function	GO:0051871	dihydrofolic acid binding	ISO	J:155856
Molecular Function	GO:0005542	folic acid binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	ISO	J:164563
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0050661	NADP binding	IBA	J:265628
Molecular Function	GO:0070402	NADPH binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:1990825	sequence-specific mRNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:223303
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1497770
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:223303
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:150202
Cellular Component	GO:0005634	nucleus	IDA	J:150202
Biological Process	GO:0031103	axon regeneration	ISO	J:155856
Biological Process	GO:0046452	dihydrofolate metabolic process	ISO	J:155856
Biological Process	GO:0046452	dihydrofolate metabolic process	IBA	J:265628
Biological Process	GO:0046655	folic acid metabolic process	ISO	J:155856
Biological Process	GO:0046655	folic acid metabolic process	IBA	J:265628
Biological Process	GO:0006545	glycine biosynthetic process	IEA	J:72247
Biological Process	GO:0006730	one-carbon metabolic process	IEA	J:60000
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	IMP	J:222680
Biological Process	GO:2000121	regulation of removal of superoxide radicals	IMP	J:222680
Biological Process	GO:0031427	response to methotrexate	IEA	J:60000
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	IMP	J:222680
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	ISO	J:155856
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	IBA	J:265628
Biological Process	GO:0035999	tetrahydrofolate interconversion	IDA	J:19257