GO Annotations Graph

• Symbol: Dlk1
• Name: delta like non-canonical Notch ligand 1
• ID: MGI:94900

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:216244
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141412
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141412
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2071906
Biological Process	GO:0030282	bone mineralization	IMP	J:233118
Biological Process	GO:0030154	cell differentiation	ISO	J:155856
Biological Process	GO:0009790	embryo development	IDA	J:146771
Biological Process	GO:0048706	embryonic skeletal system development	IDA	J:146771
Biological Process	GO:0035264	multicellular organism growth	IMP	J:233118
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:21435
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IBA	J:265628
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IGI	J:175008
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:73065
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:73065
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	IDA	J:210259
Biological Process	GO:0001503	ossification	IMP	J:233118
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:233118
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:73065
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:233118
Biological Process	GO:0001819	positive regulation of cytokine production	IDA	J:233118
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:73065
Biological Process	GO:0009791	post-embryonic development	IDA	J:146771
Biological Process	GO:0046850	regulation of bone remodeling	ISO	J:73065
Biological Process	GO:0010468	regulation of gene expression	IMP	J:150356