Dnmt1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Dnmt1
DNA methyltransferase 1
MGI:94912

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	IDA	J:202816
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	ISO	J:155856
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IDA	J:72443
Molecular Function	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	TAS	Reactome:R-MMU-5336369
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IDA	J:72443
Molecular Function	GO:0009008	DNA-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0009008	DNA-methyltransferase activity	TAS	Reactome:R-MMU-573383
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008327	methyl-CpG binding	IDA	J:163857
Molecular Function	GO:0008168	methyltransferase activity	IDA	J:113866
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:188893
Molecular Function	GO:0005515	protein binding	IPI	J:100129
Molecular Function	GO:0005515	protein binding	IPI	J:129097
Molecular Function	GO:0005515	protein binding	IPI	J:159064
Molecular Function	GO:0005515	protein binding	IPI	J:113866
Molecular Function	GO:0005515	protein binding	IPI	J:133257
Molecular Function	GO:0005515	protein binding	IPI	J:212358
Molecular Function	GO:0005515	protein binding	IPI	J:133257
Molecular Function	GO:0005515	protein binding	IPI	J:81304
Molecular Function	GO:0005515	protein binding	IPI	J:81304
Molecular Function	GO:0005515	protein binding	IPI	J:81304
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	IDA	J:163857
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IDA	J:72443
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0001674	female germ cell nucleus	IDA	J:92186
Cellular Component	GO:0043073	germ cell nucleus	IDA	J:92186
Cellular Component	GO:0043073	germ cell nucleus	IDA	J:92186
Cellular Component	GO:0000792	heterochromatin	IDA	J:86777
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336365
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5336369
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573336
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573376
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573383
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:104615
Cellular Component	GO:0005634	nucleus	IDA	J:133257
Cellular Component	GO:0005634	nucleus	IDA	J:79935
Cellular Component	GO:0005721	pericentric heterochromatin	IDA	J:150999
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0005657	replication fork	IDA	J:81304
Biological Process	GO:0090116	C-5 methylation of cytosine	IEA	J:72247
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:1903926	cellular response to bisphenol A	IDA	J:310324
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006306	DNA methylation	IMP	J:240642
Biological Process	GO:0006306	DNA methylation	IGI	J:261327
Biological Process	GO:0006306	DNA methylation	IMP	J:112224
Biological Process	GO:0006306	DNA methylation	IMP	J:202816
Biological Process	GO:0006306	DNA methylation	IDA	J:72443
Biological Process	GO:0043045	DNA methylation involved in embryo development	IMP	J:269416
Biological Process	GO:0043045	DNA methylation involved in embryo development	IGI	J:261327
Biological Process	GO:0043045	DNA methylation involved in embryo development	IMP	J:1157
Biological Process	GO:0032776	DNA methylation on cytosine	ISO	J:155856
Biological Process	GO:0032776	DNA methylation on cytosine	IMP	J:1157
Biological Process	GO:0010424	DNA methylation on cytosine within a CG sequence	ISO	J:155856
Biological Process	GO:0010424	DNA methylation on cytosine within a CG sequence	IBA	J:265628
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	IDA	J:113866
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:118209
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:118209
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:269416
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IMP	J:150999
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	ISO	J:164563
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:81304
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:112224
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:202816
Biological Process	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:1905931	negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:63662
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:63662
Biological Process	GO:0010468	regulation of gene expression	IMP	J:112614
Biological Process	GO:0010468	regulation of gene expression	IMP	J:192731
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0046500	S-adenosylmethionine metabolic process	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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