GO Annotations Graph

• Symbol: Drd4
• Name: dopamine receptor D4
• ID: MGI:94926

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035240	dopamine binding	ISO	J:164563
Molecular Function	GO:0035240	dopamine binding	ISO	J:155856
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	ISO	J:164563
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:155856
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISO	J:164563
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP	J:69457
Molecular Function	GO:0051379	epinephrine binding	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0051380	norepinephrine binding	ISO	J:164563
Molecular Function	GO:0051378	serotonin binding	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:143450
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:143450
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:143450
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:143450
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:143450
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0012506	vesicle membrane	ISO	J:155856
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IMP	J:97412
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:43061
Biological Process	GO:0050482	arachidonic acid secretion	ISO	J:164563
Biological Process	GO:0008306	associative learning	ISO	J:155856
Biological Process	GO:0001662	behavioral fear response	ISO	J:155856
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:103880
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:43061
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0007212	dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007212	dopamine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0042596	fear response	IMP	J:89406
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:97412
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:69457
Biological Process	GO:0050709	negative regulation of protein secretion	ISO	J:164563
Biological Process	GO:0050805	negative regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	ISO	J:164563
Biological Process	GO:0008355	olfactory learning	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0060406	positive regulation of penile erection	ISO	J:155856
Biological Process	GO:0032417	positive regulation of sodium:proton antiporter activity	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0050848	regulation of calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:202325
Biological Process	GO:0042053	regulation of dopamine metabolic process	IMP	J:43061
Biological Process	GO:0046928	regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	ISO	J:155856
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:143450
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IMP	J:143450
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:143450
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:143450
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	EXP	J:143450
Biological Process	GO:0001975	response to amphetamine	IMP	J:43061
Biological Process	GO:0034776	response to histamine	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007614	short-term memory	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0001963	synaptic transmission, dopaminergic	ISO	J:155856