GO Annotations Graph

• Symbol: Epha2
• Name: Eph receptor A2
• ID: MGI:95278

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005003	ephrin receptor activity	IEA	J:72247
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200429
Molecular Function	GO:0005515	protein binding	IPI	J:110334
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:238221
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0031256	leading edge membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0048320	axial mesoderm formation	IMP	J:69393
Biological Process	GO:0001568	blood vessel development	IMP	J:69393
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP	J:148922
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:148922
Biological Process	GO:0046849	bone remodeling	IMP	J:175143
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:175142
Biological Process	GO:0046058	cAMP metabolic process	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0048870	cell motility	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:148922
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048013	ephrin receptor signaling pathway	IMP	J:144621
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:88877
Biological Process	GO:0006954	inflammatory response	IMP	J:148922
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:0030216	keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0070309	lens fiber cell morphogenesis	IDA	J:144621
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:175142
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:148922
Biological Process	GO:0032682	negative regulation of chemokine production	IMP	J:148922
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:148922
Biological Process	GO:1901491	negative regulation of lymphangiogenesis	IMP	J:148922
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0021915	neural tube development	IMP	J:69393
Biological Process	GO:0030182	neuron differentiation	IDA	J:91751
Biological Process	GO:0030182	neuron differentiation	IMP	J:91751
Biological Process	GO:0060035	notochord cell development	IMP	J:69393
Biological Process	GO:0014028	notochord formation	IGI	J:69393
Biological Process	GO:0014028	notochord formation	IMP	J:69393
Biological Process	GO:0048570	notochord morphogenesis	IMP	J:69393
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:175143
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:175143
Biological Process	GO:1904238	pericyte cell differentiation	IMP	J:148922
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:69393
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0045765	regulation of angiogenesis	IDA	J:110334
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	IDA	J:110334
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010591	regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0070848	response to growth factor	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IMP	J:69393
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:69393