GO Annotations Graph

• Symbol: Edn2
• Name: endothelin 2
• ID: MGI:95284

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031708	endothelin B receptor binding	ISO	J:164563
Molecular Function	GO:0031708	endothelin B receptor binding	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IDA	J:201133
Biological Process	GO:0001525	angiogenesis	IGI	J:201133
Biological Process	GO:0014824	artery smooth muscle contraction	ISO	J:164563
Biological Process	GO:0048675	axon extension	IDA	J:133765
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0009932	cell tip growth	IDA	J:201133
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	IDA	J:201133
Biological Process	GO:0097009	energy homeostasis	IMP	J:201436
Biological Process	GO:0048016	inositol phosphate-mediated signaling	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0048286	lung alveolus development	IMP	J:201436
Biological Process	GO:0042116	macrophage activation	ISO	J:164563
Biological Process	GO:0048246	macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0046888	negative regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	IDA	J:250662
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0001543	ovarian follicle rupture	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:164563
Biological Process	GO:0046887	positive regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	ISO	J:164563
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IMP	J:149202
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	ISO	J:164563
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IBA	J:265628
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	IDA	J:17960
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	IDA	J:149202
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	ISO	J:164563
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	IBA	J:265628
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0006939	smooth muscle contraction	IDA	J:17960
Biological Process	GO:0001659	temperature homeostasis	IMP	J:201436
Biological Process	GO:0001944	vasculature development	IDA	J:201133
Biological Process	GO:0042310	vasoconstriction	ISO	J:164563
Biological Process	GO:0014826	vein smooth muscle contraction	ISO	J:164563
Biological Process	GO:0014826	vein smooth muscle contraction	IBA	J:265628