GO Annotations Graph

• Symbol: Egr2
• Name: early growth response 2
• ID: MGI:95296

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:128960
Molecular Function	GO:0003677	DNA binding	IDA	J:3739
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:52990
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:128960
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:75421
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:3739
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:285008
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0071837	HMG box domain binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200491
Molecular Function	GO:0005515	protein binding	IPI	J:128960
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:36044
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:168300
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:3739
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:285221
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0061665	SUMO ligase activity	IDA	J:200491
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:128960
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:128960
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619428
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619430
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619440
Cellular Component	GO:0005634	nucleus	IDA	J:128960
Cellular Component	GO:0005634	nucleus	IC	J:75421
Cellular Component	GO:0005634	nucleus	IDA	J:92324
Biological Process	GO:0035904	aorta development	IMP	J:230306
Biological Process	GO:0035284	brain segmentation	IMP	J:16077
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:170688
Biological Process	GO:0021612	facial nerve structural organization	IMP	J:21073
Biological Process	GO:0021612	facial nerve structural organization	IMP	J:52990
Biological Process	GO:0021612	facial nerve structural organization	IGI	J:50514
Biological Process	GO:0045444	fat cell differentiation	IMP	J:168300
Biological Process	GO:0045444	fat cell differentiation	IMP	J:129790
Biological Process	GO:0010467	gene expression	IMP	J:246383
Biological Process	GO:0010467	gene expression	IMP	J:230306
Biological Process	GO:0008045	motor neuron axon guidance	IGI	J:50514
Biological Process	GO:0042552	myelination	IMP	J:159829
Biological Process	GO:0042552	myelination	IMP	J:159829
Biological Process	GO:0042552	myelination	IMP	J:99824
Biological Process	GO:0042552	myelination	IMP	J:75421
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:128960
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:285221
Biological Process	GO:0031643	positive regulation of myelination	IMP	J:21073
Biological Process	GO:0014040	positive regulation of Schwann cell differentiation	IMP	J:52990
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:168300
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:3739
Biological Process	GO:0006611	protein export from nucleus	IDA	J:128960
Biological Process	GO:0016925	protein sumoylation	IDA	J:200491
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:75421
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:99824
Biological Process	GO:0030278	regulation of ossification	IMP	J:30822
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0021569	rhombomere 3 development	IGI	J:50514
Biological Process	GO:0021660	rhombomere 3 formation	IMP	J:16077
Biological Process	GO:0021659	rhombomere 3 structural organization	IDA	J:3739
Biological Process	GO:0021666	rhombomere 5 formation	IMP	J:16077
Biological Process	GO:0021665	rhombomere 5 structural organization	IMP	J:285221
Biological Process	GO:0021665	rhombomere 5 structural organization	IDA	J:3739
Biological Process	GO:0007622	rhythmic behavior	IDA	J:75501
Biological Process	GO:0007622	rhythmic behavior	IMP	J:75501
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:21073
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:99824
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:159829
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:116858
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918