GO Annotations Graph

• Symbol: Eng
• Name: endoglin
• ID: MGI:95392

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0036122	BMP binding	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0005534	galactose binding	ISO	J:164563
Molecular Function	GO:0005539	glycosaminoglycan binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:204744
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:18318
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IDA	J:18318
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0072563	endothelial microparticle	IDA	J:166919
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:85366
Biological Process	GO:0001525	angiogenesis	IMP	J:73415
Biological Process	GO:0048844	artery morphogenesis	IMP	J:55403
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	IMP	J:124260
Biological Process	GO:1905222	atrioventricular canal morphogenesis	IMP	J:154475
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:55403
Biological Process	GO:0003209	cardiac atrium morphogenesis	IMP	J:154475
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:154475
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0003273	cell migration involved in endocardial cushion formation	IMP	J:154475
Biological Process	GO:0048870	cell motility	ISO	J:164563
Biological Process	GO:0022009	central nervous system vasculogenesis	ISO	J:164563
Biological Process	GO:0070483	detection of hypoxia	ISO	J:164563
Biological Process	GO:0035912	dorsal aorta morphogenesis	IMP	J:85366
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:85366
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:154475
Biological Process	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:154475
Biological Process	GO:0070278	extracellular matrix constituent secretion	ISO	J:155856
Biological Process	GO:0022617	extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0007507	heart development	IMP	J:73415
Biological Process	GO:0007507	heart development	IMP	J:58502
Biological Process	GO:0001947	heart looping	IMP	J:55403
Biological Process	GO:0001947	heart looping	IMP	J:154475
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:85366
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0031953	negative regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0003148	outflow tract septum morphogenesis	IGI	J:124260
Biological Process	GO:0045766	positive regulation of angiogenesis	TAS	J:164086
Biological Process	GO:0045766	positive regulation of angiogenesis	IGI	J:204744
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:154475
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:154475
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:154475
Biological Process	GO:1905065	positive regulation of vascular associated smooth muscle cell differentiation	IMP	J:124260
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	TAS	J:73415
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0048745	smooth muscle tissue development	IMP	J:55403
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IC	J:18318
Biological Process	GO:0097084	vascular associated smooth muscle cell development	IMP	J:124260
Biological Process	GO:0001570	vasculogenesis	ISO	J:164563
Biological Process	GO:0001570	vasculogenesis	IMP	J:55403
Biological Process	GO:0001570	vasculogenesis	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:58502
Biological Process	GO:0048845	venous blood vessel morphogenesis	IMP	J:55403
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	IMP	J:154475
Biological Process	GO:0042060	wound healing	ISO	J:164563