GO Annotations Graph

• Symbol: Epo
• Name: erythropoietin
• ID: MGI:95407

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005128	erythropoietin receptor binding	TAS	J:169941
Molecular Function	GO:0005128	erythropoietin receptor binding	ISO	J:164563
Molecular Function	GO:0005128	erythropoietin receptor binding	IBA	J:265628
Molecular Function	GO:0005179	hormone activity	IEA	J:72247
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0030295	protein kinase activator activity	IDA	J:173139
Molecular Function	GO:0030295	protein kinase activator activity	IBA	J:265628
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006326
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006327
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9006329
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9012652
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9012653
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9012656
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9027266
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9029147
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9030346
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9030353
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:90918
Biological Process	GO:0001525	angiogenesis	TAS	J:169941
Biological Process	GO:0006915	apoptotic process	IDA	J:127025
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	TAS	J:169941
Biological Process	GO:0071474	cellular hyperosmotic response	ISO	J:164563
Biological Process	GO:0007566	embryo implantation	IDA	J:127025
Biological Process	GO:0030218	erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0030218	erythrocyte differentiation	IDA	J:98445
Biological Process	GO:0043249	erythrocyte maturation	IEA	J:60000
Biological Process	GO:0038162	erythropoietin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038162	erythropoietin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0003007	heart morphogenesis	TAS	J:169941
Biological Process	GO:0042541	hemoglobin biosynthetic process	IDA	J:127025
Biological Process	GO:0033028	myeloid cell apoptotic process	IDA	J:141453
Biological Process	GO:0033028	myeloid cell apoptotic process	IDA	J:141453
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:173139
Biological Process	GO:0010523	negative regulation of calcium ion transport into cytosol	ISO	J:164563
Biological Process	GO:2001258	negative regulation of cation channel activity	ISO	J:164563
Biological Process	GO:1902251	negative regulation of erythrocyte apoptotic process	ISO	J:164563
Biological Process	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ISO	J:164563
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	IDA	J:141453
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:173139
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:173139
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:127025
Biological Process	GO:0001666	response to hypoxia	IDA	J:90918
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	TAS	J:169941
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	TAS	J:169941
Biological Process	GO:0061032	visceral serous pericardium development	TAS	J:169941