Erbb3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Erbb3
erb-b2 receptor tyrosine kinase 3
MGI:95411

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0038132	neuregulin binding	ISO	J:164563
Molecular Function	GO:0038132	neuregulin binding	ISO	J:155856
Molecular Function	GO:0038132	neuregulin binding	IBA	J:265628
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:155856
Molecular Function	GO:0038131	neuregulin receptor activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:203534
Molecular Function	GO:0005515	protein binding	IPI	J:168371
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IDA	J:34905
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:317053
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:94401
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0038143	ERBB3:ERBB2 complex	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:94401
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:317053
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0021545	cranial nerve development	IMP	J:43515
Biological Process	GO:0021545	cranial nerve development	IMP	J:43515
Biological Process	GO:0003197	endocardial cushion development	IMP	J:45302
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:34905
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:317053
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:43515
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:43515
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:43515
Biological Process	GO:0051048	negative regulation of secretion	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:43515
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:43515
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:45302
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	IGI	J:144171
Biological Process	GO:0055025	positive regulation of cardiac muscle tissue development	IMP	J:210551
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:210551
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:43515
Biological Process	GO:0014037	Schwann cell differentiation	IMP	J:43515
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:73065

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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