GO Annotations Graph

• Symbol: Fas
• Name: Fas cell surface death receptor
• ID: MGI:95484

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IDA	J:30163
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:217283
Molecular Function	GO:0005515	protein binding	IPI	J:166031
Molecular Function	GO:0005515	protein binding	IPI	J:184109
Molecular Function	GO:0005515	protein binding	IPI	J:113685
Molecular Function	GO:0005515	protein binding	IPI	J:139785
Molecular Function	GO:0005515	protein binding	IPI	J:177240
Molecular Function	GO:0005515	protein binding	IPI	J:65176
Molecular Function	GO:0005515	protein binding	IPI	J:41242
Molecular Function	GO:0005515	protein binding	IPI	J:200420
Molecular Function	GO:0005515	protein binding	IPI	J:171939
Molecular Function	GO:0005515	protein binding	IPI	J:30163
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	ISO	J:155856
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IBA	J:265628
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	IDA	J:177240
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:29455
Cellular Component	GO:0009986	cell surface	IDA	J:97777
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31364
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31364
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:87420
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:196136
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:125784
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:104536
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:97777
Cellular Component	GO:0005576	extracellular region	IDA	J:29455
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0006924	activation-induced cell death of T cells	IBA	J:265628
Biological Process	GO:0006924	activation-induced cell death of T cells	IMP	J:26199
Biological Process	GO:0006924	activation-induced cell death of T cells	IMP	J:31852
Biological Process	GO:0006924	activation-induced cell death of T cells	IMP	J:26199
Biological Process	GO:0006924	activation-induced cell death of T cells	IDA	J:84826
Biological Process	GO:0006915	apoptotic process	IMP	J:34351
Biological Process	GO:0006915	apoptotic process	IMP	J:34351
Biological Process	GO:0006915	apoptotic process	ISO	J:73065
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:33466
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:17445
Biological Process	GO:0019724	B cell mediated immunity	IMP	J:131363
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071455	cellular response to hyperoxia	ISO	J:164563
Biological Process	GO:0071285	cellular response to lithium ion	IMP	J:163720
Biological Process	GO:0007623	circadian rhythm	IEP	J:199564
Biological Process	GO:0031104	dendrite regeneration	ISO	J:155856
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:78039
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:141457
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:85525
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:85525
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:172906
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:87420
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:89131
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:113782
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:141606
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:88139
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:30163
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:97777
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:56164
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IGI	J:88139
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:87420
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IMP	J:30163
Biological Process	GO:0036337	Fas signaling pathway	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:26199
Biological Process	GO:0010467	gene expression	IMP	J:26199
Biological Process	GO:0097284	hepatocyte apoptotic process	IGI	J:209127
Biological Process	GO:0097284	hepatocyte apoptotic process	IGI	J:209127
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002377	immunoglobulin production	IMP	J:131363
Biological Process	GO:0006925	inflammatory cell apoptotic process	IMP	J:87420
Biological Process	GO:0006925	inflammatory cell apoptotic process	IDA	J:87420
Biological Process	GO:0070227	lymphocyte apoptotic process	IDA	J:97777
Biological Process	GO:0097049	motor neuron apoptotic process	IBA	J:265628
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:85525
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:85525
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097527	necroptotic signaling pathway	IBA	J:265628
Biological Process	GO:0097527	necroptotic signaling pathway	IGI	J:182381
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:29455
Biological Process	GO:0050869	negative regulation of B cell activation	IMP	J:7488
Biological Process	GO:1900148	negative regulation of Schwann cell migration	ISO	J:155856
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	ISO	J:155856
Biological Process	GO:0045060	negative thymic T cell selection	IMP	J:56164
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:163720
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	IDA	J:172906
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	IC	J:172906
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045577	regulation of B cell differentiation	IMP	J:7488
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	IMP	J:48838
Biological Process	GO:0045637	regulation of myeloid cell differentiation	IMP	J:48838
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	IBA	J:265628
Biological Process	GO:0045580	regulation of T cell differentiation	IMP	J:7488
Biological Process	GO:0051384	response to glucocorticoid	IMP	J:31852
Biological Process	GO:0051384	response to glucocorticoid	IMP	J:26199
Biological Process	GO:0051384	response to glucocorticoid	IMP	J:26199
Biological Process	GO:0009636	response to toxic substance	IMP	J:31382
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0048536	spleen development	IMP	J:131363
Biological Process	GO:0043029	T cell homeostasis	IMP	J:31852
Biological Process	GO:0043029	T cell homeostasis	IMP	J:31852