GO Annotations Graph

• Symbol: Fbn1
• Name: fibrillin 1
• ID: MGI:95489

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0005201	extracellular matrix structural constituent	ISO	J:164563
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0005201	extracellular matrix structural constituent	IBA	J:265628
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	IDA	J:319868
Molecular Function	GO:0005179	hormone activity	IDA	J:314392
Molecular Function	GO:0005179	hormone activity	IDA	J:279017
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0005179	hormone activity	IDA	J:251851
Molecular Function	GO:0005179	hormone activity	IDA	J:313846
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:160041
Molecular Function	GO:0005515	protein binding	IPI	J:221347
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:235251
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:118147
Cellular Component	GO:0031012	extracellular matrix	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:251851
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0001527	microfibril	ISO	J:164563
Cellular Component	GO:0001527	microfibril	TAS	J:165256
Cellular Component	GO:0001527	microfibril	TAS	J:25216
Cellular Component	GO:0001527	microfibril	IDA	J:226844
Cellular Component	GO:0001527	microfibril	IDA	J:226844
Biological Process	GO:0034199	activation of protein kinase A activity	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0006006	glucose metabolic process	ISO	J:164563
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0001822	kidney development	ISO	J:155856
Biological Process	GO:0001656	metanephros development	ISO	J:155856
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	IMP	J:314912
Biological Process	GO:0046676	negative regulation of insulin secretion	IDA	J:313846
Biological Process	GO:2001205	negative regulation of osteoclast development	ISO	J:164563
Biological Process	GO:2001205	negative regulation of osteoclast development	IDA	J:235251
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IDA	J:235251
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0032100	positive regulation of appetite	IDA	J:251851
Biological Process	GO:0010737	protein kinase A signaling	ISO	J:164563
Biological Process	GO:0035582	sequestering of BMP in extracellular matrix	IMP	J:165256
Biological Process	GO:0035583	sequestering of TGFbeta in extracellular matrix	IMP	J:165256
Biological Process	GO:0001501	skeletal system development	ISO	J:164563