GO Annotations Graph

• Symbol: Fgfr4
• Name: fibroblast growth factor receptor 4
• ID: MGI:95525

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	IBA	J:265628
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	IBA	J:265628
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	ISO	J:73065
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	ISO	J:73065
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:156501
Molecular Function	GO:0005515	protein binding	IPI	J:121336
Molecular Function	GO:0005515	protein binding	IPI	J:110570
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0030133	transport vesicle	ISO	J:164563
Biological Process	GO:0061144	alveolar secondary septum development	IGI	J:50677
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:62267
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:153198
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:153198
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0042593	glucose homeostasis	IMP	J:126527
Biological Process	GO:0030324	lung development	IMP	J:94299
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0090272	negative regulation of fibroblast growth factor production	IGI	J:206158
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:206158
Biological Process	GO:0001759	organ induction	IMP	J:94299
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0055062	phosphate ion homeostasis	IMP	J:175280
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:153198
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:153198
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	IGI	J:206158
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	IMP	J:62267
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	ISO	J:164563
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	IBA	J:265628
Biological Process	GO:0010715	regulation of extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:126527
Biological Process	GO:0010966	regulation of phosphate transport	IGI	J:206158
Biological Process	GO:0051174	regulation of phosphorus metabolic process	IGI	J:206158
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0070640	vitamin D3 metabolic process	IGI	J:206158