GO Annotations Graph

• Symbol: Ccn2
• Name: cellular communication network factor 2
• ID: MGI:95537

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001968	fibronectin binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	IBA	J:265628
Molecular Function	GO:0008201	heparin binding	IDA	J:40574
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	IDA	J:56877
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005801	cis-Golgi network	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0031012	extracellular matrix	IDA	J:40574
Cellular Component	GO:0005576	extracellular region	IDA	J:11407
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IDA	J:56877
Biological Process	GO:0001525	angiogenesis	IDA	J:53931
Biological Process	GO:0001525	angiogenesis	IMP	J:83260
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:155856
Biological Process	GO:0001502	cartilage condensation	IDA	J:91724
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0016477	cell migration	IDA	J:53931
Biological Process	GO:0007160	cell-matrix adhesion	IDA	J:40574
Biological Process	GO:0002062	chondrocyte differentiation	IDA	J:91724
Biological Process	GO:0035988	chondrocyte proliferation	IMP	J:155442
Biological Process	GO:0061448	connective tissue development	IMP	J:202628
Biological Process	GO:0071897	DNA biosynthetic process	IEA	J:60000
Biological Process	GO:0070278	extracellular matrix constituent secretion	ISO	J:155856
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IDA	J:40574
Biological Process	GO:0007229	integrin-mediated signaling pathway	IDA	J:56877
Biological Process	GO:0007229	integrin-mediated signaling pathway	IDA	J:53931
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0030324	lung development	IMP	J:130165
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:155442
Biological Process	GO:0001503	ossification	IMP	J:67852
Biological Process	GO:0001503	ossification	IMP	J:83260
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0050867	positive regulation of cell activation	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0072593	reactive oxygen species metabolic process	IDA	J:149902
Biological Process	GO:0032330	regulation of chondrocyte differentiation	IMP	J:155442
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0001894	tissue homeostasis	IMP	J:202628