GO Annotations Graph

• Symbol: Flg
• Name: filaggrin
• ID: MGI:95553

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990254	keratin filament binding	IDA	J:202807
Molecular Function	GO:0030280	structural constituent of skin epidermis	IDA	J:202807
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0001533	cornified envelope	IDA	J:171374
Cellular Component	GO:0001533	cornified envelope	IDA	J:73258
Cellular Component	GO:0036457	keratohyalin granule	IDA	J:230728
Cellular Component	GO:0036457	keratohyalin granule	IDA	J:6708
Biological Process	GO:0008544	epidermis development	IMP	J:202453
Biological Process	GO:0008544	epidermis development	IMP	J:5286
Biological Process	GO:0061436	establishment of skin barrier	IMP	J:192725
Biological Process	GO:0045109	intermediate filament organization	IDA	J:202807
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000