GO Annotations Graph

• Symbol: Flna
• Name: filamin, alpha
• ID: MGI:95556

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	TAS	J:51716
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0034988	Fc-gamma receptor I complex binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0051020	GTPase binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0031852	mu-type opioid receptor binding	ISO	J:155856
Molecular Function	GO:0015459	potassium channel regulator activity	IMP	J:212181
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:51716
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:144247
Molecular Function	GO:0005515	protein binding	IPI	J:66484
Molecular Function	GO:0005515	protein binding	IPI	J:79977
Molecular Function	GO:0005515	protein binding	IPI	J:210363
Molecular Function	GO:0005515	protein binding	IPI	J:36107
Molecular Function	GO:0005515	protein binding	IPI	J:210363
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IDA	J:86198
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:231247
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0032432	actin filament bundle	IDA	J:210363
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0044295	axonal growth cone	IDA	J:281211
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0030863	cortical cytoskeleton	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:1990779	glycoprotein Ib-IX-V complex	NAS	J:320061
Cellular Component	GO:0030426	growth cone	IDA	J:231247
Cellular Component	GO:0031523	Myb complex	ISO	J:137631
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:51716
Cellular Component	GO:0030018	Z disc	IDA	J:212181
Biological Process	GO:0051764	actin crosslink formation	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:174390
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:118252
Biological Process	GO:0007597	blood coagulation, intrinsic pathway	NAS	J:320061
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:118252
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:118252
Biological Process	GO:0060271	cilium assembly	ISO	J:164563
Biological Process	GO:0051220	cytoplasmic sequestering of protein	ISO	J:164563
Biological Process	GO:0045022	early endosome to late endosome transport	IDA	J:51716
Biological Process	GO:0001837	epithelial to mesenchymal transition	IGI	J:174390
Biological Process	GO:0045184	establishment of protein localization	ISO	J:164563
Biological Process	GO:0097368	establishment of Sertoli cell barrier	ISO	J:155856
Biological Process	GO:0021943	formation of radial glial scaffolds	ISO	J:155856
Biological Process	GO:0003007	heart morphogenesis	IMP	J:118252
Biological Process	GO:0035855	megakaryocyte development	NAS	J:320061
Biological Process	GO:0090307	mitotic spindle assembly	ISO	J:137631
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	IGI	J:231247
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0016479	negative regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	ISO	J:155856
Biological Process	GO:0048680	positive regulation of axon regeneration	IMP	J:281211
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:2001224	positive regulation of neuron migration	ISO	J:155856
Biological Process	GO:0010572	positive regulation of platelet activation	NAS	J:320061
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	IMP	J:212181
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:1902396	protein localization to bicellular tight junction	ISO	J:155856
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:212181
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0043113	receptor clustering	ISO	J:164563
Biological Process	GO:0032231	regulation of actin filament bundle assembly	IMP	J:165730
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential	IC	J:212181
Biological Process	GO:1905031	regulation of membrane repolarization during cardiac muscle cell action potential	IMP	J:212181
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	NAS	J:320061
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IEP	J:231247
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IGI	J:231247
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	ISO	J:164563
Biological Process	GO:0050808	synapse organization	IDA	J:234716
Biological Process	GO:0050808	synapse organization	IDA	J:234716
Biological Process	GO:0050808	synapse organization	IMP	J:234716
Biological Process	GO:0090042	tubulin deacetylation	ISO	J:164563
Biological Process	GO:0044319	wound healing, spreading of cells	ISO	J:164563