Flt1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Flt1
FMS-like tyrosine kinase 1
MGI:95558

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0019838	growth factor binding	ISO	J:155856
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:103507
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0036332	placental growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:268024
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	ISO	J:164563
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IBA	J:265628
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IDA	J:91451
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:223264
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:191431
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0001525	angiogenesis	TAS	J:49507
Biological Process	GO:0001525	angiogenesis	IMP	J:90967
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:26845
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:90967
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	IMP	J:49507
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0016477	cell migration	IGI	J:95386
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048598	embryonic morphogenesis	IMP	J:26845
Biological Process	GO:1990384	hyaloid vascular plexus regression	IMP	J:279052
Biological Process	GO:0030522	intracellular receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002548	monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	ISO	J:155856
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:1904046	negative regulation of vascular endothelial growth factor production	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	IMP	J:204805
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0010863	positive regulation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048597	post-embryonic camera-type eye morphogenesis	IGI	J:183383
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006940	regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IMP	J:204805
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:152835
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP	J:49507
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IC	J:91451
Biological Process	GO:0036323	vascular endothelial growth factor receptor-1 signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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