GO Annotations Graph

• Symbol: Flt3
• Name: FMS-like tyrosine kinase 3
• ID: MGI:95559

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0004896	cytokine receptor activity	IMP	J:136209
Molecular Function	GO:0019838	growth factor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IDA	J:18780
Molecular Function	GO:0005515	protein binding	IPI	J:56367
Molecular Function	GO:0005515	protein binding	IPI	J:18780
Molecular Function	GO:0005515	protein binding	IPI	J:36245
Molecular Function	GO:0005515	protein binding	IPI	J:162445
Molecular Function	GO:0005515	protein binding	IPI	J:16458
Molecular Function	GO:0005515	protein binding	IPI	J:23709
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:140548
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:213100
Cellular Component	GO:0009986	cell surface	IDA	J:47896
Cellular Component	GO:0009986	cell surface	IDA	J:27743
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:203580
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604768
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604980
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9605258
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9606621
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9606623
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9606789
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9607226
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9609272
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9645128
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9645133
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9645136
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0019882	antigen processing and presentation	IMP	J:159599
Biological Process	GO:0030183	B cell differentiation	IMP	J:170520
Biological Process	GO:0030183	B cell differentiation	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:72247
Biological Process	GO:0008283	cell population proliferation	IMP	J:21273
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:136209
Biological Process	GO:0098586	cellular response to virus	IMP	J:159599
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	IMP	J:177063
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:136209
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0097028	dendritic cell differentiation	IMP	J:136209
Biological Process	GO:0036145	dendritic cell homeostasis	IMP	J:159599
Biological Process	GO:0030097	hemopoiesis	ISO	J:16485
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IGI	J:189096
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:159599
Biological Process	GO:0001776	leukocyte homeostasis	IMP	J:136209
Biological Process	GO:0048535	lymph node development	IMP	J:159599
Biological Process	GO:0030098	lymphocyte differentiation	IDA	J:79569
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:136209
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IMP	J:136209
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IMP	J:133528
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IGI	J:27238
Biological Process	GO:0045578	negative regulation of B cell differentiation	IDA	J:108330
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:21273
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:159599
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:159599
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:159599
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:159599
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:159599
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IGI	J:162445
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IGI	J:162445
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:159599
Biological Process	GO:0009791	post-embryonic development	IGI	J:189096
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:170520
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:27238
Biological Process	GO:0002572	pro-T cell differentiation	IMP	J:27238
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:18780
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:140548
Biological Process	GO:0006468	protein phosphorylation	IGI	J:162445
Biological Process	GO:0006468	protein phosphorylation	IGI	J:162445
Biological Process	GO:0048536	spleen development	IGI	J:189096
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628