GO Annotations Graph

• Symbol: Fmr1
• Name: fragile X messenger ribonucleoprotein 1
• ID: MGI:95564

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:214397
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0070840	dynein complex binding	IDA	J:137197
Molecular Function	GO:0002151	G-quadruplex RNA binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035064	methylated histone binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	IDA	J:137197
Molecular Function	GO:0008017	microtubule binding	IDA	J:132042
Molecular Function	GO:0035198	miRNA binding	IDA	J:167653
Molecular Function	GO:0035198	miRNA binding	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IDA	J:87312
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IDA	J:231207
Molecular Function	GO:0003730	mRNA 3'-UTR binding	ISO	J:164563
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IBA	J:265628
Molecular Function	GO:0048027	mRNA 5'-UTR binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	IDA	J:87312
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	ISO	J:155856
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	ISO	J:164563
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA binding	IDA	J:285490
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0034046	poly(G) binding	ISO	J:164563
Molecular Function	GO:0034046	poly(G) binding	ISO	J:164563
Molecular Function	GO:0008266	poly(U) RNA binding	ISO	J:164563
Molecular Function	GO:0008266	poly(U) RNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:232981
Molecular Function	GO:0005515	protein binding	IPI	J:231209
Molecular Function	GO:0005515	protein binding	IPI	J:231287
Molecular Function	GO:0005515	protein binding	IPI	J:231248
Molecular Function	GO:0005515	protein binding	IPI	J:88664
Molecular Function	GO:0005515	protein binding	IPI	J:156046
Molecular Function	GO:0005515	protein binding	IPI	J:230638
Molecular Function	GO:0005515	protein binding	IPI	J:137197
Molecular Function	GO:0005515	protein binding	IPI	J:188613
Molecular Function	GO:0005515	protein binding	IPI	J:231210
Molecular Function	GO:0005515	protein binding	IPI	J:132042
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0000340	RNA 7-methylguanosine cap binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IDA	J:211150
Molecular Function	GO:0035613	RNA stem-loop binding	ISO	J:164563
Molecular Function	GO:0033592	RNA strand annealing activity	ISO	J:164563
Molecular Function	GO:1990825	sequence-specific mRNA binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0035197	siRNA binding	ISO	J:164563
Molecular Function	GO:0031369	translation initiation factor binding	ISO	J:164563
Molecular Function	GO:0045182	translation regulator activity	ISO	J:155856
Molecular Function	GO:0045182	translation regulator activity	ISO	J:164563
Molecular Function	GO:0045182	translation regulator activity	IBA	J:265628
Molecular Function	GO:0045182	translation regulator activity	IDA	J:76865
Molecular Function	GO:0045182	translation regulator activity	IMP	J:76865
Molecular Function	GO:0030371	translation repressor activity	ISO	J:164563
Molecular Function	GO:0030371	translation repressor activity	IDA	J:231207
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0030424	axon	IDA	J:111946
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:144942
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0015030	Cajal body	ISO	J:164563
Cellular Component	GO:0044297	cell body	ISO	J:132042
Cellular Component	GO:0042995	cell projection	ISO	J:164563
Cellular Component	GO:0010369	chromocenter	IDA	J:214397
Cellular Component	GO:0005694	chromosome	IDA	J:214397
Cellular Component	GO:0000775	chromosome, centromeric region	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:231287
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:231248
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	J:137197
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:155856
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	IBA	J:265628
Cellular Component	GO:0010494	cytoplasmic stress granule	ISO	J:155856
Cellular Component	GO:0010494	cytoplasmic stress granule	ISO	J:164563
Cellular Component	GO:0010494	cytoplasmic stress granule	IDA	J:177884
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:111946
Cellular Component	GO:0030425	dendrite	IDA	J:137197
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:144942
Cellular Component	GO:0030425	dendrite	IDA	J:179583
Cellular Component	GO:1902737	dendritic filopodium	IDA	J:137197
Cellular Component	GO:1902737	dendritic filopodium	ISO	J:155856
Cellular Component	GO:1902737	dendritic filopodium	IDA	J:111946
Cellular Component	GO:1902737	dendritic filopodium	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	IDA	J:111946
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IDA	J:137197
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0044327	dendritic spine head	ISO	J:155856
Cellular Component	GO:0044326	dendritic spine neck	ISO	J:155856
Cellular Component	GO:0044326	dendritic spine neck	IBA	J:265628
Cellular Component	GO:0019897	extrinsic component of plasma membrane	IDA	J:231248
Cellular Component	GO:0032433	filopodium tip	IDA	J:111946
Cellular Component	GO:0097386	glial cell projection	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:144942
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:144942
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:144942
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:144942
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0030426	growth cone	IBA	J:265628
Cellular Component	GO:1990812	growth cone filopodium	IDA	J:111946
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:144942
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:144942
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:1990124	messenger ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:132042
Cellular Component	GO:0005845	mRNA cap binding complex	IDA	J:156046
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0071598	neuronal ribonucleoprotein granule	IDA	J:137197
Cellular Component	GO:0071598	neuronal ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0071598	neuronal ribonucleoprotein granule	ISO	J:132042
Cellular Component	GO:0071598	neuronal ribonucleoprotein granule	IDA	J:177884
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:83170
Cellular Component	GO:0005634	nucleus	IDA	J:83170
Cellular Component	GO:0043204	perikaryon	IDA	J:87312
Cellular Component	GO:0043204	perikaryon	ISO	J:164563
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	IDA	J:144942
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:231287
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005844	polysome	ISO	J:155856
Cellular Component	GO:0005844	polysome	ISO	J:164563
Cellular Component	GO:0005844	polysome	IDA	J:87312
Cellular Component	GO:0005844	polysome	IDA	J:97555
Cellular Component	GO:0005844	polysome	IBA	J:265628
Cellular Component	GO:0098794	postsynapse	IDA	J:123208
Cellular Component	GO:0098794	postsynapse	IDA	J:144942
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0098793	presynapse	IDA	J:144942
Cellular Component	GO:0098793	presynapse	IBA	J:265628
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:0099523	presynaptic cytosol	IDA	J:144942
Cellular Component	GO:1990635	proximal dendrite	ISO	J:155856
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:76865
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:76865
Cellular Component	GO:0032797	SMN complex	IDA	J:230624
Cellular Component	GO:0032797	SMN complex	ISO	J:164563
Cellular Component	GO:0005790	smooth endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0097444	spine apparatus	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:111946
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0008089	anterograde axonal transport	IMP	J:228023
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	IMP	J:83170
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IDA	J:214397
Biological Process	GO:0098976	excitatory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:121659
Biological Process	GO:0007215	glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:70178
Biological Process	GO:0007215	glutamate receptor signaling pathway	IDA	J:137197
Biological Process	GO:0098977	inhibitory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0044830	modulation by host of viral RNA genome replication	ISO	J:164563
Biological Process	GO:0006406	mRNA export from nucleus	ISO	J:164563
Biological Process	GO:0006406	mRNA export from nucleus	IDA	J:285490
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0051028	mRNA transport	IDA	J:137197
Biological Process	GO:2000766	negative regulation of cytoplasmic translation	IDA	J:231207
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:194411
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	IMP	J:70178
Biological Process	GO:1902373	negative regulation of mRNA catabolic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010955	negative regulation of protein processing	ISO	J:155856
Biological Process	GO:0002091	negative regulation of receptor internalization	ISO	J:155856
Biological Process	GO:2000301	negative regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	IDA	J:87312
Biological Process	GO:0017148	negative regulation of translation	IMP	J:242173
Biological Process	GO:0017148	negative regulation of translation	IBA	J:265628
Biological Process	GO:0045947	negative regulation of translational initiation	IDA	J:156046
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0140694	non-membrane-bounded organelle assembly	ISO	J:164563
Biological Process	GO:0060999	positive regulation of dendritic spine development	IDA	J:137197
Biological Process	GO:0051491	positive regulation of filopodium assembly	IDA	J:137197
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1901254	positive regulation of intracellular transport of viral material	ISO	J:164563
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	ISO	J:155856
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	ISO	J:164563
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	IDA	J:167653
Biological Process	GO:1902416	positive regulation of mRNA binding	ISO	J:164563
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	IDA	J:231248
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0050806	positive regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	IMP	J:144699
Biological Process	GO:0045727	positive regulation of translation	IBA	J:265628
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	J:173059
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IBA	J:265628
Biological Process	GO:0060998	regulation of dendritic spine development	ISO	J:164563
Biological Process	GO:0060998	regulation of dendritic spine development	IMP	J:111946
Biological Process	GO:0051489	regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0051489	regulation of filopodium assembly	IMP	J:111946
Biological Process	GO:0051489	regulation of filopodium assembly	IBA	J:265628
Biological Process	GO:0060964	regulation of miRNA-mediated gene silencing	ISO	J:164563
Biological Process	GO:1905244	regulation of modification of synaptic structure	IMP	J:101021
Biological Process	GO:0043488	regulation of mRNA stability	IMP	J:121659
Biological Process	GO:0043488	regulation of mRNA stability	IBA	J:265628
Biological Process	GO:0098908	regulation of neuronal action potential	ISO	J:164563
Biological Process	GO:0098908	regulation of neuronal action potential	ISO	J:155856
Biological Process	GO:0046928	regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0006417	regulation of translation	IEA	J:72247
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	IMP	J:145490
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	IMP	J:76865
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	IDA	J:76865
Biological Process	GO:0099577	regulation of translation at presynapse, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0097396	response to interleukin-17	IMP	J:289937
Biological Process	GO:0008380	RNA splicing	IEA	J:60000
Biological Process	GO:0031047	RNA-mediated gene silencing	IEA	J:60000
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0035176	social behavior	IMP	J:289937
Biological Process	GO:0034063	stress granule assembly	ISO	J:164563
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:263307