GO Annotations Graph

• Symbol: Folr1
• Name: folate receptor alpha
• ID: MGI:95568

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005542	folic acid binding	ISO	J:164563
Molecular Function	GO:0005542	folic acid binding	ISO	J:155856
Molecular Function	GO:0005542	folic acid binding	TAS	J:66219
Molecular Function	GO:0061714	folic acid receptor activity	ISO	J:164563
Molecular Function	GO:0061714	folic acid receptor activity	TAS	J:66219
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0038023	signaling receptor activity	TAS	J:66219
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005903	brush border	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	TAS	J:66219
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0061713	anterior neural tube closure	IMP	J:124492
Biological Process	GO:0031103	axon regeneration	IMP	J:161646
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	J:124492
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0071231	cellular response to folic acid	ISO	J:164563
Biological Process	GO:1904447	folate import across plasma membrane	IEA	J:72247
Biological Process	GO:0046655	folic acid metabolic process	IMP	J:84731
Biological Process	GO:0015884	folic acid transport	ISO	J:164563
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	IBA	J:265628
Biological Process	GO:0001947	heart looping	IMP	J:124492
Biological Process	GO:0003147	neural crest cell migration involved in heart formation	IMP	J:124492
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:124492
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	TAS	J:66219
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	IMP	J:222232
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IMP	J:222232
Biological Process	GO:0048678	response to axon injury	IMP	J:161646
Biological Process	GO:0035036	sperm-egg recognition	IBA	J:265628