GO Annotations Graph

• Symbol: Fyn
• Name: Fyn proto-oncogene
• ID: MGI:95602

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	IDA	J:74532
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042609	CD4 receptor binding	ISO	J:155856
Molecular Function	GO:0042610	CD8 receptor binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	IPI	J:205618
Molecular Function	GO:0070851	growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051428	peptide hormone receptor binding	ISO	J:155856
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:220495
Molecular Function	GO:0005515	protein binding	IPI	J:200344
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:148067
Molecular Function	GO:0005515	protein binding	IPI	J:269564
Molecular Function	GO:0005515	protein binding	IPI	J:164597
Molecular Function	GO:0005515	protein binding	IPI	J:239186
Molecular Function	GO:0005515	protein binding	IPI	J:33665
Molecular Function	GO:0005515	protein binding	IPI	J:111421
Molecular Function	GO:0005515	protein binding	IPI	J:41194
Molecular Function	GO:0005515	protein binding	IPI	J:200358
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:200348
Molecular Function	GO:0005515	protein binding	IPI	J:53497
Molecular Function	GO:0005515	protein binding	IPI	J:248810
Molecular Function	GO:0005515	protein binding	IPI	J:41036
Molecular Function	GO:0005515	protein binding	IPI	J:107755
Molecular Function	GO:0005515	protein binding	IPI	J:128987
Molecular Function	GO:0005515	protein binding	IPI	J:107755
Molecular Function	GO:0005515	protein binding	IPI	J:18500
Molecular Function	GO:0005515	protein binding	IPI	J:41036
Molecular Function	GO:0005515	protein binding	IPI	J:48282
Molecular Function	GO:0005515	protein binding	IPI	J:73962
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:41036
Molecular Function	GO:0005515	protein binding	IPI	J:35635
Molecular Function	GO:0005515	protein binding	IPI	J:41036
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IDA	J:74532
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:131771
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:82731
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-3928613
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-9763891
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-MMU-983702
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	Reactome:R-NUL-420398
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:248810
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:250573
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:132344
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:128987
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:158624
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:217241
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:18500
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:17973
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0042608	T cell receptor binding	ISO	J:155856
Molecular Function	GO:0048156	tau protein binding	IPI	J:74532
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:82577
Molecular Function	GO:0015631	tubulin binding	IDA	J:74532
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	ISO	J:155856
Cellular Component	GO:0005884	actin filament	IDA	J:125001
Cellular Component	GO:0044297	cell body	IDA	J:74532
Cellular Component	GO:0071944	cell periphery	IDA	J:125001
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1433273
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2395436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928613
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928635
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-420382
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-420394
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9605258
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680706
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682572
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763891
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763892
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763903
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9764150
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9817994
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9818009
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-983702
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-420386
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-420388
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-420398
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-421136
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-421138
Cellular Component	GO:0030425	dendrite	IMP	J:164597
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:125001
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0097386	glial cell projection	IDA	J:74532
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	IDA	J:74532
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9032771
Cellular Component	GO:0005886	plasma membrane	IDA	J:66300
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IMP	J:164597
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:3417
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:3417
Biological Process	GO:0050798	activated T cell proliferation	IMP	J:70886
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:40461
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:1905430	cellular response to glycine	ISO	J:155856
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:1905232	cellular response to L-glutamate	ISO	J:155856
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IDA	J:125001
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IGI	J:176254
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IGI	J:176254
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:107755
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IMP	J:101558
Biological Process	GO:0030900	forebrain development	IMP	J:103576
Biological Process	GO:0030900	forebrain development	IGI	J:101055
Biological Process	GO:0030900	forebrain development	IMP	J:103576
Biological Process	GO:0003015	heart process	IGI	J:237245
Biological Process	GO:0003015	heart process	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:205618
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:3417
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:3417
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042552	myelination	TAS	J:74532
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	IGI	J:190064
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:166919
Biological Process	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1903202	negative regulation of oxidative stress-induced cell death	ISO	J:155856
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:132344
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IDA	J:217241
Biological Process	GO:0001764	neuron migration	IGI	J:101055
Biological Process	GO:0001764	neuron migration	IGI	J:101055
Biological Process	GO:0001764	neuron migration	IMP	J:103576
Biological Process	GO:0001764	neuron migration	IMP	J:103576
Biological Process	GO:0031175	neuron projection development	IGI	J:133207
Biological Process	GO:0031175	neuron projection development	IGI	J:133207
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:237245
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:82731
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:250573
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:18500
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:17973
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:43707
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:128987
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:128987
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:205618
Biological Process	GO:1901216	positive regulation of neuron death	IGI	J:190064
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:133207
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IMP	J:158624
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	IDA	J:158624
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IGI	J:190064
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:203754
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:17973
Biological Process	GO:0030163	protein catabolic process	IMP	J:132344
Biological Process	GO:0006468	protein phosphorylation	IMP	J:101558
Biological Process	GO:0006468	protein phosphorylation	IMP	J:52965
Biological Process	GO:0016567	protein ubiquitination	IDA	J:217241
Biological Process	GO:1905664	regulation of calcium ion import across plasma membrane	IGI	J:190064
Biological Process	GO:0008360	regulation of cell shape	IDA	J:74532
Biological Process	GO:1900449	regulation of glutamate receptor signaling pathway	IGI	J:190064
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IGI	J:190064
Biological Process	GO:1904645	response to amyloid-beta	IGI	J:190064
Biological Process	GO:0045471	response to ethanol	IGI	J:43707
Biological Process	GO:0000304	response to singlet oxygen	ISO	J:155856
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628