GO Annotations Graph

• Symbol: Gba1
• Name: glucosylceramidase beta 1
• ID: MGI:95665

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008422	beta-glucosidase activity	IDA	J:286765
Molecular Function	GO:0008422	beta-glucosidase activity	IMP	J:286765
Molecular Function	GO:0004336	galactosylceramidase activity	IEA	J:72245
Molecular Function	GO:0004348	glucosylceramidase activity	IDA	J:268017
Molecular Function	GO:0004348	glucosylceramidase activity	IMP	J:174780
Molecular Function	GO:0004348	glucosylceramidase activity	ISO	J:164563
Molecular Function	GO:0004348	glucosylceramidase activity	ISO	J:155856
Molecular Function	GO:0004348	glucosylceramidase activity	IMP	J:199258
Molecular Function	GO:0004348	glucosylceramidase activity	IBA	J:265628
Molecular Function	GO:0004348	glucosylceramidase activity	IDA	J:286765
Molecular Function	GO:0004348	glucosylceramidase activity	IMP	J:286765
Molecular Function	GO:0046527	glucosyltransferase activity	ISO	J:164563
Molecular Function	GO:0046527	glucosyltransferase activity	IDA	J:268017
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IDA	J:164482
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:269546
Molecular Function	GO:0005124	scavenger receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:131449
Molecular Function	GO:0050295	steryl-beta-glucosidase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:269546
Cellular Component	GO:0005615	extracellular space	IDA	J:164482
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:269546
Cellular Component	GO:0043202	lysosomal lumen	IDA	J:131449
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:131449
Cellular Component	GO:0005764	lysosome	IDA	J:269546
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:269546
Biological Process	GO:0019882	antigen processing and presentation	IMP	J:185511
Biological Process	GO:1905037	autophagosome organization	IMP	J:199258
Biological Process	GO:0006914	autophagy	IMP	J:237861
Biological Process	GO:0006914	autophagy	ISO	J:164563
Biological Process	GO:0006914	autophagy	IMP	J:199258
Biological Process	GO:1901805	beta-glucoside catabolic process	ISO	J:155856
Biological Process	GO:0048854	brain morphogenesis	IMP	J:127108
Biological Process	GO:0048469	cell maturation	IMP	J:185511
Biological Process	GO:0009267	cellular response to starvation	IMP	J:199258
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	IMP	J:136093
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:0021694	cerebellar Purkinje cell layer formation	IMP	J:127108
Biological Process	GO:0008203	cholesterol metabolic process	IDA	J:268017
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:136093
Biological Process	GO:0061436	establishment of skin barrier	ISO	J:155856
Biological Process	GO:0006680	glucosylceramide catabolic process	IMP	J:199258
Biological Process	GO:0006680	glucosylceramide catabolic process	ISO	J:164563
Biological Process	GO:0006680	glucosylceramide catabolic process	IMP	J:174780
Biological Process	GO:0006680	glucosylceramide catabolic process	IDA	J:268017
Biological Process	GO:0006680	glucosylceramide catabolic process	IBA	J:265628
Biological Process	GO:0006678	glucosylceramide metabolic process	IMP	J:127108
Biological Process	GO:0006678	glucosylceramide metabolic process	IMP	J:136093
Biological Process	GO:0071425	hematopoietic stem cell proliferation	IMP	J:185511
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:127108
Biological Process	GO:0030259	lipid glycosylation	IDA	J:268017
Biological Process	GO:0030259	lipid glycosylation	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0019915	lipid storage	IMP	J:127108
Biological Process	GO:0072676	lymphocyte migration	IMP	J:185511
Biological Process	GO:0007040	lysosome organization	IMP	J:237861
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0014004	microglia differentiation	IMP	J:127108
Biological Process	GO:0061518	microglial cell proliferation	IMP	J:127108
Biological Process	GO:0007005	mitochondrion organization	IMP	J:199258
Biological Process	GO:0000423	mitophagy	IMP	J:199258
Biological Process	GO:0061744	motor behavior	IMP	J:127108
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:127108
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0051248	negative regulation of protein metabolic process	IMP	J:211953
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	IMP	J:199258
Biological Process	GO:0050877	nervous system process	IMP	J:127108
Biological Process	GO:0050877	nervous system process	IMP	J:136093
Biological Process	GO:0050905	neuromuscular process	IMP	J:136093
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:127108
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:136093
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	IMP	J:199258
Biological Process	GO:1904457	positive regulation of neuronal action potential	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:199258
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:1903061	positive regulation of protein lipidation	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0043243	positive regulation of protein-containing complex disassembly	ISO	J:164563
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	IMP	J:174780
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:199258
Biological Process	GO:0021859	pyramidal neuron differentiation	IMP	J:127108
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:199258
Biological Process	GO:0051246	regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0051246	regulation of protein metabolic process	IMP	J:199258
Biological Process	GO:0032006	regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:237861
Biological Process	GO:0022904	respiratory electron transport chain	IMP	J:199258
Biological Process	GO:0071548	response to dexamethasone	ISO	J:155856
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0009268	response to pH	ISO	J:155856
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0097066	response to thyroid hormone	ISO	J:155856
Biological Process	GO:0098773	skin epidermis development	ISO	J:155856
Biological Process	GO:0006665	sphingolipid metabolic process	IEA	J:72247
Biological Process	GO:0006665	sphingolipid metabolic process	IEA	J:60000
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:185511
Biological Process	GO:0035745	T-helper 2 cell cytokine production	IMP	J:185511
Biological Process	GO:0023021	termination of signal transduction	ISO	J:164563