GO Annotations Graph

• Symbol: Gch1
• Name: GTP cyclohydrolase 1
• ID: MGI:95675

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	IBA	J:265628
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	ISO	J:155856
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	IBA	J:265628
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	ISO	J:73065
Molecular Function	GO:0003934	GTP cyclohydrolase I activity	IDA	J:20569
Molecular Function	GO:0030742	GTP-dependent protein binding	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031369	translation initiation factor binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TAS	J:237677
Biological Process	GO:0051066	dihydrobiopterin metabolic process	ISO	J:155856
Biological Process	GO:0042416	dopamine biosynthetic process	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0050884	neuromuscular process controlling posture	ISO	J:73065
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:219813
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0042559	pteridine-containing compound biosynthetic process	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:109694
Biological Process	GO:0014916	regulation of lung blood pressure	IMP	J:109694
Biological Process	GO:2000121	regulation of removal of superoxide radicals	ISO	J:164563
Biological Process	GO:1905627	regulation of serotonin biosynthetic process	NAS	J:237675
Biological Process	GO:0048265	response to pain	ISO	J:155856
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	ISO	J:164563
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	IBA	J:265628
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	IC	J:20569
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	IEA	J:72247
Biological Process	GO:0042311	vasodilation	ISO	J:155856