GO Annotations Graph

• Symbol: Gdf3
• Name: growth differentiation factor 3
• ID: MGI:95686

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:104371
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0007492	endoderm development	IGI	J:127541
Biological Process	GO:0007492	endoderm development	IMP	J:104371
Biological Process	GO:0001654	eye development	ISO	J:164563
Biological Process	GO:0048859	formation of anatomical boundary	IMP	J:104371
Biological Process	GO:0001701	in utero embryonic development	IGI	J:127541
Biological Process	GO:0001701	in utero embryonic development	IMP	J:127541
Biological Process	GO:0001701	in utero embryonic development	IMP	J:104371
Biological Process	GO:0007498	mesoderm development	IGI	J:127541
Biological Process	GO:0007498	mesoderm development	IMP	J:104371
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0045605	negative regulation of epidermal cell differentiation	ISO	J:164563
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IMP	J:204300
Biological Process	GO:0030903	notochord development	IMP	J:104371
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:239199
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0090009	primitive streak formation	IMP	J:104371
Biological Process	GO:0010453	regulation of cell fate commitment	ISO	J:164563
Biological Process	GO:0002021	response to dietary excess	IMP	J:136322
Biological Process	GO:0007165	signal transduction	IMP	J:127541
Biological Process	GO:0001501	skeletal system development	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0032525	somite rostral/caudal axis specification	IMP	J:104371