GO Annotations Graph

• Symbol: Gdf5
• Name: growth differentiation factor 5
• ID: MGI:95688

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0036122	BMP binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:91306
Molecular Function	GO:0005515	protein binding	IPI	J:87049
Molecular Function	GO:0005515	protein binding	IPI	J:88556
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0051216	cartilage development	IEA	J:60000
Biological Process	GO:0060591	chondroblast differentiation	ISO	J:164563
Biological Process	GO:0002062	chondrocyte differentiation	IDA	J:52419
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:94510
Biological Process	GO:0035136	forelimb morphogenesis	IMP	J:17582
Biological Process	GO:0035137	hindlimb morphogenesis	IMP	J:17582
Biological Process	GO:0035137	hindlimb morphogenesis	IMP	J:124813
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	IMP	J:94510
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	ISO	J:164563
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IGI	J:141606
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IDA	J:52419
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:124813
Biological Process	GO:0060390	regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606