GO Annotations Graph

• Symbol: Mstn
• Name: myostatin
• ID: MGI:95691

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	IDA	J:242410
Molecular Function	GO:0008201	heparin binding	IDA	J:236214
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IDA	J:242410
Molecular Function	GO:0005515	protein binding	IPI	J:85741
Molecular Function	GO:0005515	protein binding	IPI	J:162988
Molecular Function	GO:0005515	protein binding	IPI	J:162988
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:236214
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:70668
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:70668
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-9625523
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:85741
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	IDA	J:199171
Biological Process	GO:0046716	muscle cell cellular homeostasis	ISO	J:164563
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration	IMP	J:150456
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP	J:101518
Biological Process	GO:0033673	negative regulation of kinase activity	IMP	J:219087
Biological Process	GO:0014741	negative regulation of muscle hypertrophy	ISO	J:155856
Biological Process	GO:0045662	negative regulation of myoblast differentiation	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	ISO	J:164563
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:75344
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:205290
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:40054
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:171042
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	ISO	J:155856
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:132807
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	IMP	J:132807
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	IMP	J:150456
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IMP	J:150456
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0014816	skeletal muscle satellite cell differentiation	IMP	J:234367
Biological Process	GO:0043403	skeletal muscle tissue regeneration	IMP	J:234367
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:85741