GO Annotations Graph

• Symbol: Gh
• Name: growth hormone
• ID: MGI:95707

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005131	growth hormone receptor binding	IBA	J:265628
Molecular Function	GO:0005131	growth hormone receptor binding	ISO	J:73065
Molecular Function	GO:0005131	growth hormone receptor binding	ISO	J:73065
Molecular Function	GO:0005131	growth hormone receptor binding	IPI	J:58419
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005148	prolactin receptor binding	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1168910
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1168923
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1168927
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169142
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169194
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169206
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169229
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169240
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1169250
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:102449
Cellular Component	GO:0005615	extracellular space	IDA	J:29213
Cellular Component	GO:0070195	growth hormone receptor complex	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:40378
Cellular Component	GO:0005886	plasma membrane	IDA	J:40378
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:15586
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:40378
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:129482
Biological Process	GO:0060396	growth hormone receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048286	lung alveolus development	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0007405	neuroblast proliferation	ISO	J:155856
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	ISO	J:73065
Biological Process	GO:0045927	positive regulation of growth	ISO	J:155856
Biological Process	GO:0045927	positive regulation of growth	IBA	J:265628
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IGI	J:106071
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	ISO	J:73065
Biological Process	GO:0032094	response to food	IDA	J:129482
Biological Process	GO:0009416	response to light stimulus	ISO	J:155856
Biological Process	GO:0031667	response to nutrient levels	IBA	J:265628