GO Annotations Graph

• Symbol: Ghr
• Name: growth hormone receptor
• ID: MGI:95708

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IEA	J:72247
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IBA	J:265628
Molecular Function	GO:0004903	growth hormone receptor activity	ISO	J:155856
Molecular Function	GO:0004903	growth hormone receptor activity	IBA	J:265628
Molecular Function	GO:0004903	growth hormone receptor activity	IDA	J:7060
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	IBA	J:265628
Molecular Function	GO:0017046	peptide hormone binding	IPI	J:58419
Molecular Function	GO:0005515	protein binding	IPI	J:34907
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1168790
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0070195	growth hormone receptor complex	ISO	J:164563
Cellular Component	GO:0070195	growth hormone receptor complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:74664
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:40378
Cellular Component	GO:0005634	nucleus	IDA	J:40378
Cellular Component	GO:0005634	nucleus	IDA	J:40378
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1168790
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1168910
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1168923
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1168927
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169142
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169194
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169206
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169229
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169240
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169250
Cellular Component	GO:0005886	plasma membrane	IDA	J:40378
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:155856
Biological Process	GO:0032870	cellular response to hormone stimulus	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:7060
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0060396	growth hormone receptor signaling pathway	IDA	J:34907
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060396	growth hormone receptor signaling pathway	IBA	J:265628
Biological Process	GO:0042445	hormone metabolic process	ISO	J:164563
Biological Process	GO:0009755	hormone-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0040018	positive regulation of multicellular organism growth	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:34907
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IBA	J:265628
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:138238
Biological Process	GO:0032355	response to estradiol	ISO	J:164563
Biological Process	GO:0019530	taurine metabolic process	IMP	J:138238