GO Annotations Graph

• Symbol: Gja1
• Name: gap junction protein, alpha 1
• ID: MGI:95713

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0048487	beta-tubulin binding	IDA	J:90107
Molecular Function	GO:0071253	connexin binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:155856
Molecular Function	GO:0015562	efflux transmembrane transporter activity	IMP	J:279975
Molecular Function	GO:0015562	efflux transmembrane transporter activity	IMP	J:279975
Molecular Function	GO:0005243	gap junction channel activity	ISO	J:164563
Molecular Function	GO:0005243	gap junction channel activity	IMP	J:268027
Molecular Function	GO:0005243	gap junction channel activity	ISO	J:164563
Molecular Function	GO:0005243	gap junction channel activity	ISO	J:155856
Molecular Function	GO:0005243	gap junction channel activity	IBA	J:265628
Molecular Function	GO:0005243	gap junction channel activity	IDA	J:74146
Molecular Function	GO:0005243	gap junction channel activity	IDA	J:90107
Molecular Function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	TAS	J:227218
Molecular Function	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	ISO	J:164563
Molecular Function	GO:0055077	gap junction hemi-channel activity	ISO	J:164563
Molecular Function	GO:0034634	glutathione transmembrane transporter activity	IMP	J:279975
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:155856
Molecular Function	GO:0015075	monoatomic ion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:222156
Molecular Function	GO:0005515	protein binding	IPI	J:273516
Molecular Function	GO:0005515	protein binding	IPI	J:268027
Molecular Function	GO:0005515	protein binding	IPI	J:200309
Molecular Function	GO:0005515	protein binding	IPI	J:169070
Molecular Function	GO:0005515	protein binding	IPI	J:222137
Molecular Function	GO:0005515	protein binding	IPI	J:212352
Molecular Function	GO:0005515	protein binding	IPI	J:245272
Molecular Function	GO:0005515	protein binding	IPI	J:139618
Molecular Function	GO:0005515	protein binding	IPI	J:222149
Molecular Function	GO:0005515	protein binding	IPI	J:227218
Molecular Function	GO:0005515	protein binding	IPI	J:222149
Molecular Function	GO:0005515	protein binding	IPI	J:222143
Molecular Function	GO:0005515	protein binding	IPI	J:181983
Molecular Function	GO:0005515	protein binding	IPI	J:90107
Molecular Function	GO:0005515	protein binding	IPI	J:93341
Molecular Function	GO:0005515	protein binding	IPI	J:93341
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:240293
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:240293
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:190290
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:92523
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:92523
Molecular Function	GO:0022857	transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0015631	tubulin binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:268027
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:48407
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IDA	J:94694
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:170926
Cellular Component	GO:0005911	cell-cell junction	IDA	J:92523
Cellular Component	GO:0005911	cell-cell junction	IDA	J:90107
Cellular Component	GO:0005922	connexin complex	ISO	J:155856
Cellular Component	GO:0005922	connexin complex	IBA	J:265628
Cellular Component	GO:0043292	contractile fiber	IDA	J:174203
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:48407
Cellular Component	GO:0005829	cytosol	IDA	J:92523
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005916	fascia adherens	ISO	J:155856
Cellular Component	GO:0005916	fascia adherens	IDA	J:73178
Cellular Component	GO:0005921	gap junction	IDA	J:24121
Cellular Component	GO:0005921	gap junction	ISO	J:164563
Cellular Component	GO:0005921	gap junction	ISO	J:155856
Cellular Component	GO:0005921	gap junction	IDA	J:86412
Cellular Component	GO:0005921	gap junction	IDA	J:102628
Cellular Component	GO:0005921	gap junction	IDA	J:90107
Cellular Component	GO:0005921	gap junction	IDA	J:165948
Cellular Component	GO:0005921	gap junction	IDA	J:159723
Cellular Component	GO:0005921	gap junction	IDA	J:84125
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:90107
Cellular Component	GO:0014704	intercalated disc	ISO	J:164563
Cellular Component	GO:0014704	intercalated disc	IDA	J:127606
Cellular Component	GO:0014704	intercalated disc	IDA	J:227218
Cellular Component	GO:0014704	intercalated disc	IDA	J:93341
Cellular Component	GO:0014704	intercalated disc	IDA	J:238852
Cellular Component	GO:0014704	intercalated disc	IDA	J:161910
Cellular Component	GO:0005882	intermediate filament	IDA	J:125067
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:48407
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:156343
Cellular Component	GO:0016020	membrane	IDA	J:90107
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005771	multivesicular body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:240293
Cellular Component	GO:0005886	plasma membrane	IDA	J:227218
Cellular Component	GO:0005886	plasma membrane	IDA	J:92523
Cellular Component	GO:0005886	plasma membrane	IDA	J:117855
Cellular Component	GO:0005886	plasma membrane	IDA	J:90107
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0070160	tight junction	ISO	J:164563
Biological Process	GO:0007512	adult heart development	IMP	J:46473
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0015867	ATP transport	ISO	J:155856
Biological Process	GO:0003294	atrial ventricular junction remodeling	IGI	J:110256
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:108525
Biological Process	GO:0060348	bone development	IMP	J:269543
Biological Process	GO:0046849	bone remodeling	IMP	J:269543
Biological Process	GO:0061337	cardiac conduction	IMP	J:39599
Biological Process	GO:0061337	cardiac conduction	IMP	J:110256
Biological Process	GO:0007154	cell communication	ISO	J:155856
Biological Process	GO:0010643	cell communication by chemical coupling	IDA	J:90107
Biological Process	GO:0010644	cell communication by electrical coupling	IBA	J:265628
Biological Process	GO:0010644	cell communication by electrical coupling	IDA	J:90107
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:48407
Biological Process	GO:0007267	cell-cell signaling	ISO	J:155856
Biological Process	GO:0007267	cell-cell signaling	IBA	J:265628
Biological Process	GO:0007267	cell-cell signaling	IDA	J:74146
Biological Process	GO:1904646	cellular response to amyloid-beta	IMP	J:279975
Biological Process	GO:0071467	cellular response to pH	IDA	J:240293
Biological Process	GO:0002544	chronic inflammatory response	ISO	J:155856
Biological Process	GO:0002069	columnar/cuboidal epithelial cell maturation	IMP	J:108525
Biological Process	GO:0002069	columnar/cuboidal epithelial cell maturation	IMP	J:108525
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:150209
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:87369
Biological Process	GO:0003347	epicardial cell to mesenchymal cell transition	TAS	J:169941
Biological Process	GO:0090162	establishment of epithelial cell polarity	TAS	J:169941
Biological Process	GO:0140115	export across plasma membrane	IMP	J:279975
Biological Process	GO:0014047	glutamate secretion	IMP	J:279975
Biological Process	GO:0007507	heart development	IMP	J:24121
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:108525
Biological Process	GO:0001947	heart looping	IMP	J:46473
Biological Process	GO:0001701	in utero embryonic development	IMP	J:46473
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:48407
Biological Process	GO:0035437	maintenance of protein localization in endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0008584	male gonad development	IMP	J:122838
Biological Process	GO:0060156	milk ejection reflex	IMP	J:159723
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	IMP	J:224741
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:150209
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:155856
Biological Process	GO:0097402	neuroblast migration	IMP	J:104850
Biological Process	GO:0001764	neuron migration	IMP	J:104850
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:181527
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:82985
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:82985
Biological Process	GO:2000987	positive regulation of behavioral fear response	ISO	J:155856
Biological Process	GO:0010652	positive regulation of cell communication by chemical coupling	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249887
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1904446	positive regulation of establishment of Sertoli cell barrier	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:150209
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:150209
Biological Process	GO:0003104	positive regulation of glomerular filtration	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0045836	positive regulation of meiotic nuclear division	ISO	J:155856
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:155856
Biological Process	GO:0045844	positive regulation of striated muscle tissue development	IMP	J:94694
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0110053	regulation of actin filament organization	ISO	J:155856
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	IMP	J:110256
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	ISO	J:155856
Biological Process	GO:0060312	regulation of blood vessel remodeling	TAS	J:169941
Biological Process	GO:0030500	regulation of bone mineralization	IMP	J:182985
Biological Process	GO:0030500	regulation of bone mineralization	IMP	J:182985
Biological Process	GO:0046850	regulation of bone remodeling	IMP	J:182985
Biological Process	GO:0046850	regulation of bone remodeling	IMP	J:182985
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	ISO	J:155856
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:91971
Biological Process	GO:0008016	regulation of heart contraction	IMP	J:74146
Biological Process	GO:0022898	regulation of transmembrane transporter activity	ISO	J:155856
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IMP	J:110256
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IMP	J:39599
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IGI	J:110256
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IGI	J:110256
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	J:110256
Biological Process	GO:0009268	response to pH	ISO	J:155856
Biological Process	GO:0043403	skeletal muscle tissue regeneration	IDA	J:94694
Biological Process	GO:0007283	spermatogenesis	IMP	J:122838
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856
Biological Process	GO:0042110	T cell activation	IDA	J:179248
Biological Process	GO:0042098	T cell proliferation	IMP	J:269549
Biological Process	GO:0055085	transmembrane transport	ISO	J:155856
Biological Process	GO:0010232	vascular transport	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042908	xenobiotic transport	IMP	J:279975