GO Annotations Graph

• Symbol: Gja5
• Name: gap junction protein, alpha 5
• ID: MGI:95716

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071253	connexin binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:155856
Molecular Function	GO:0005243	gap junction channel activity	ISO	J:155856
Molecular Function	GO:0086076	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling	ISO	J:164563
Molecular Function	GO:0086076	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling	IBA	J:265628
Molecular Function	GO:0086077	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	ISO	J:164563
Molecular Function	GO:0086078	gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling	IMP	J:250159
Molecular Function	GO:0086078	gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling	ISO	J:164563
Molecular Function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	ISO	J:164563
Molecular Function	GO:0055077	gap junction hemi-channel activity	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005922	connexin complex	ISO	J:164563
Cellular Component	GO:0005922	connexin complex	ISO	J:155856
Cellular Component	GO:0005922	connexin complex	IBA	J:265628
Cellular Component	GO:0005921	gap junction	ISO	J:164563
Cellular Component	GO:0005921	gap junction	IDA	J:46429
Cellular Component	GO:0014704	intercalated disc	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0048844	artery morphogenesis	IMP	J:161949
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	ISO	J:164563
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	IMP	J:117425
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	IBA	J:265628
Biological Process	GO:0003283	atrial septum development	ISO	J:164563
Biological Process	GO:0060413	atrial septum morphogenesis	IMP	J:110256
Biological Process	GO:0003294	atrial ventricular junction remodeling	IMP	J:110256
Biological Process	GO:0086067	AV node cell to bundle of His cell communication	IMP	J:117425
Biological Process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling	IMP	J:117425
Biological Process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling	ISO	J:164563
Biological Process	GO:0001568	blood vessel development	IMP	J:80178
Biological Process	GO:0097746	blood vessel diameter maintenance	IMP	J:80509
Biological Process	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling	IMP	J:250159
Biological Process	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling	ISO	J:164563
Biological Process	GO:0061337	cardiac conduction	IMP	J:46430
Biological Process	GO:0061337	cardiac conduction	IMP	J:155156
Biological Process	GO:0061337	cardiac conduction	IMP	J:46429
Biological Process	GO:0061337	cardiac conduction	IMP	J:117425
Biological Process	GO:0061337	cardiac conduction	IMP	J:110256
Biological Process	GO:0003161	cardiac conduction system development	IMP	J:155156
Biological Process	GO:0003161	cardiac conduction system development	IMP	J:179977
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0010643	cell communication by chemical coupling	ISO	J:155856
Biological Process	GO:0010644	cell communication by electrical coupling	ISO	J:155856
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	ISO	J:164563
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	IMP	J:113087
Biological Process	GO:0086065	cell communication involved in cardiac conduction	IMP	J:80509
Biological Process	GO:0007267	cell-cell signaling	IBA	J:265628
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:179977
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:87369
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:99177
Biological Process	GO:0035922	foramen ovale closure	IMP	J:110256
Biological Process	GO:0016264	gap junction assembly	ISO	J:164563
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0003174	mitral valve development	ISO	J:164563
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0003105	negative regulation of glomerular filtration	ISO	J:155856
Biological Process	GO:0003151	outflow tract morphogenesis	ISO	J:164563
Biological Process	GO:0010652	positive regulation of cell communication by chemical coupling	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0006813	potassium ion transport	ISO	J:155856
Biological Process	GO:0003193	pulmonary valve formation	ISO	J:164563
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	ISO	J:164563
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	IMP	J:117425
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	IMP	J:110256
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	IMP	J:46429
Biological Process	GO:0098904	regulation of AV node cell action potential	IMP	J:117425
Biological Process	GO:0098904	regulation of AV node cell action potential	ISO	J:164563
Biological Process	GO:0098905	regulation of bundle of His cell action potential	ISO	J:164563
Biological Process	GO:0098905	regulation of bundle of His cell action potential	IMP	J:117425
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	ISO	J:155856
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:113087
Biological Process	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential	IMP	J:46429
Biological Process	GO:0098906	regulation of Purkinje myocyte action potential	ISO	J:164563
Biological Process	GO:1900133	regulation of renin secretion into blood stream	IMP	J:133709
Biological Process	GO:0003073	regulation of systemic arterial blood pressure	IMP	J:80509
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IMP	J:250159
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IGI	J:110256
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IMP	J:117425
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IMP	J:46429
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	J:250159
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	J:110256
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IGI	J:110256
Biological Process	GO:0003071	renal system process involved in regulation of systemic arterial blood pressure	IMP	J:133709
Biological Process	GO:0086015	SA node cell action potential	IMP	J:113087
Biological Process	GO:0003284	septum primum development	IMP	J:110256
Biological Process	GO:0001501	skeletal system development	IMP	J:99177
Biological Process	GO:0001501	skeletal system development	IMP	J:99177
Biological Process	GO:0001501	skeletal system development	IMP	J:99177
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:1990029	vasomotion	ISO	J:155856
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	IMP	J:46429
Biological Process	GO:0003281	ventricular septum development	ISO	J:164563
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:110256