GO Annotations Graph

• Symbol: Gli2
• Name: GLI-Kruppel family member GLI2
• ID: MGI:95728

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:104380
Molecular Function	GO:0003682	chromatin binding	IDA	J:104380
Molecular Function	GO:0003682	chromatin binding	IDA	J:104380
Molecular Function	GO:0003682	chromatin binding	IDA	J:104380
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:192563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:111401
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:111401
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:221866
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:248252
Molecular Function	GO:0005515	protein binding	IPI	J:114033
Molecular Function	GO:0005515	protein binding	IPI	J:211322
Molecular Function	GO:0005515	protein binding	IPI	J:221866
Molecular Function	GO:0005515	protein binding	IPI	J:170532
Molecular Function	GO:0005515	protein binding	IPI	J:108433
Molecular Function	GO:0005515	protein binding	IPI	J:151923
Molecular Function	GO:0005515	protein binding	IPI	J:147574
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:95234
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:111401
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA	J:72247
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:108433
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:146198
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005930	axoneme	IDA	J:168317
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0097542	ciliary tip	IDA	J:255486
Cellular Component	GO:0097542	ciliary tip	IDA	J:175371
Cellular Component	GO:0005929	cilium	IDA	J:168317
Cellular Component	GO:0005929	cilium	IDA	J:218232
Cellular Component	GO:0005929	cilium	IDA	J:153142
Cellular Component	GO:0005929	cilium	IDA	J:260445
Cellular Component	GO:0005929	cilium	IDA	J:147574
Cellular Component	GO:0005929	cilium	IDA	J:153142
Cellular Component	GO:0005929	cilium	IDA	J:115756
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005929	cilium	IDA	J:185270
Cellular Component	GO:0005737	cytoplasm	IGI	J:103171
Cellular Component	GO:0005737	cytoplasm	IDA	J:151923
Cellular Component	GO:0005737	cytoplasm	IDA	J:147574
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5610710
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610711
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610714
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610715
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610751
Cellular Component	GO:0016020	membrane	IDA	J:147574
Cellular Component	GO:0031514	motile cilium	IDA	J:138713
Cellular Component	GO:0016607	nuclear speck	IDA	J:151923
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8986307
Cellular Component	GO:0005634	nucleus	IDA	J:114033
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:221866
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:151923
Cellular Component	GO:0005634	nucleus	IDA	J:115756
Cellular Component	GO:0005634	nucleus	IDA	J:138713
Cellular Component	GO:0005634	nucleus	IDA	J:147574
Cellular Component	GO:0005634	nucleus	IDA	J:103171
Biological Process	GO:0048856	anatomical structure development	IMP	J:70870
Biological Process	GO:0048856	anatomical structure development	IGI	J:70870
Biological Process	GO:0048856	anatomical structure development	IGI	J:70870
Biological Process	GO:0048856	anatomical structure development	IMP	J:70870
Biological Process	GO:0048856	anatomical structure development	IGI	J:70870
Biological Process	GO:0048856	anatomical structure development	IMP	J:70870
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	IGI	J:49603
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:188038
Biological Process	GO:0007411	axon guidance	IMP	J:54746
Biological Process	GO:0007411	axon guidance	IMP	J:54746
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:49603
Biological Process	GO:0030154	cell differentiation	IMP	J:49251
Biological Process	GO:0030154	cell differentiation	IMP	J:49164
Biological Process	GO:0008283	cell population proliferation	IMP	J:94461
Biological Process	GO:0008283	cell population proliferation	IMP	J:49603
Biological Process	GO:0008283	cell population proliferation	IMP	J:94461
Biological Process	GO:0008283	cell population proliferation	IGI	J:94461
Biological Process	GO:0008283	cell population proliferation	IGI	J:100687
Biological Process	GO:0008283	cell population proliferation	IMP	J:49603
Biological Process	GO:0008283	cell population proliferation	IGI	J:94461
Biological Process	GO:0008283	cell population proliferation	IMP	J:49603
Biological Process	GO:0008283	cell population proliferation	IMP	J:49603
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:145723
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0021696	cerebellar cortex morphogenesis	IMP	J:108507
Biological Process	GO:0021696	cerebellar cortex morphogenesis	IGI	J:108507
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:194393
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:121232
Biological Process	GO:0048589	developmental growth	IMP	J:108509
Biological Process	GO:0048589	developmental growth	IMP	J:108509
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IDA	J:41861
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:147574
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:138713
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IDA	J:41861
Biological Process	GO:0009953	dorsal/ventral pattern formation	IGI	J:106158
Biological Process	GO:0048566	embryonic digestive tract development	IMP	J:60446
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:145182
Biological Process	GO:0009913	epidermal cell differentiation	ISO	J:164563
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:100687
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:49603
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49164
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0021508	floor plate formation	IMP	J:49251
Biological Process	GO:0010467	gene expression	IMP	J:262053
Biological Process	GO:0010467	gene expression	IMP	J:192563
Biological Process	GO:0031069	hair follicle morphogenesis	ISO	J:164563
Biological Process	GO:0060322	head development	IMP	J:145182
Biological Process	GO:0007507	heart development	IGI	J:113186
Biological Process	GO:0030902	hindbrain development	IGI	J:94461
Biological Process	GO:0030902	hindbrain development	IMP	J:30339
Biological Process	GO:0030902	hindbrain development	IMP	J:94461
Biological Process	GO:0007442	hindgut morphogenesis	IMP	J:70870
Biological Process	GO:0007442	hindgut morphogenesis	IGI	J:70870
Biological Process	GO:0001701	in utero embryonic development	IMP	J:145182
Biological Process	GO:0001822	kidney development	IGI	J:113186
Biological Process	GO:0030324	lung development	IMP	J:49603
Biological Process	GO:0030324	lung development	IGI	J:60986
Biological Process	GO:0030879	mammary gland development	IMP	J:72024
Biological Process	GO:0060603	mammary gland duct morphogenesis	IMP	J:72024
Biological Process	GO:0002009	morphogenesis of an epithelium	IMP	J:144902
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:145182
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	IMP	J:121301
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:249800
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:108433
Biological Process	GO:0021915	neural tube development	IMP	J:145182
Biological Process	GO:0048666	neuron development	IMP	J:102358
Biological Process	GO:0030182	neuron differentiation	IGI	J:112802
Biological Process	GO:0030182	neuron differentiation	IGI	J:112802
Biological Process	GO:0060032	notochord regression	IGI	J:60986
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:49252
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:49252
Biological Process	GO:0002076	osteoblast development	IDA	J:111401
Biological Process	GO:0002076	osteoblast development	IMP	J:111401
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:186236
Biological Process	GO:0007389	pattern specification process	IMP	J:30339
Biological Process	GO:0007389	pattern specification process	IGI	J:87223
Biological Process	GO:0021983	pituitary gland development	IGI	J:60986
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:94461
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:145182
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:94461
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:164782
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:115756
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:121301
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:95234
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:138713
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:100687
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:49603
Biological Process	GO:0045666	positive regulation of neuron differentiation	IGI	J:112802
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:49603
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:112802
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:111401
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:111401
Biological Process	GO:0060513	prostatic bud formation	IMP	J:144902
Biological Process	GO:0009954	proximal/distal pattern formation	IGI	J:106158
Biological Process	GO:0009954	proximal/distal pattern formation	IGI	J:106158
Biological Process	GO:1901620	regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI	J:243907
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001501	skeletal system development	IMP	J:38381
Biological Process	GO:0007224	smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0007224	smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:146198
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:145182
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:146198
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI	J:121232
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI	J:158583
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	IMP	J:108507
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	IGI	J:108507
Biological Process	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IGI	J:92067
Biological Process	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	IGI	J:92067
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	IMP	J:104803
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	IMP	J:73074
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	IGI	J:104803
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	IGI	J:92067
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:188764
Biological Process	GO:0021965	spinal cord ventral commissure morphogenesis	IMP	J:54746
Biological Process	GO:0072089	stem cell proliferation	IMP	J:49603
Biological Process	GO:0035295	tube development	IGI	J:49603
Biological Process	GO:0035295	tube development	IGI	J:49603
Biological Process	GO:0007418	ventral midline development	IGI	J:60986
Biological Process	GO:0007418	ventral midline development	IMP	J:60986
Biological Process	GO:0021517	ventral spinal cord development	IMP	J:73074