GO Annotations Graph

• Symbol: Gna12
• Name: guanine nucleotide binding protein, alpha 12
• ID: MGI:95767

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031752	D5 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0031752	D5 dopamine receptor binding	IBA	J:265628
Molecular Function	GO:0001664	G protein-coupled receptor binding	IEA	J:72247
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA	J:265628
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	TAS	J:43154
Molecular Function	GO:0003924	GTPase activity	ISA	J:10067
Molecular Function	GO:0019001	guanyl nucleotide binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:164563
Molecular Function	GO:0019888	protein phosphatase regulator activity	ISO	J:164563
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005834	heterotrimeric G-protein complex	IBA	J:265628
Cellular Component	GO:0005834	heterotrimeric G-protein complex	TAS	J:53243
Cellular Component	GO:0005834	heterotrimeric G-protein complex	TAS	J:43154
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IDA	J:43154
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:77728
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:43154
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:281765
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISA	J:10067
Biological Process	GO:0001701	in utero embryonic development	IGI	J:77728
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:53243
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:281765
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:281765
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	IGI	J:255410
Biological Process	GO:0008360	regulation of cell shape	IDA	J:53243
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:190487
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:190487
Biological Process	GO:0032006	regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032006	regulation of TOR signaling	IMP	J:190487
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	IDA	J:53243
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:60000