GO Annotations Graph

• Symbol: Gnai2
• Name: G protein subunit alpha i2
• ID: MGI:95772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	IBA	J:265628
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA	J:265628
Molecular Function	GO:0005525	GTP binding	ISA	J:8410
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0019001	guanyl nucleotide binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:20413
Cellular Component	GO:0044297	cell body	IDA	J:74178
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:74178
Cellular Component	GO:0005834	heterotrimeric G-protein complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8964229
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	J:35134
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISA	J:8410
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IPI	J:88364
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	IMP	J:69295
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	ISO	J:155856
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	IBA	J:265628
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ISO	J:155856
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	ISO	J:155856
Biological Process	GO:1903614	negative regulation of protein tyrosine phosphatase activity	ISO	J:155856
Biological Process	GO:0050805	negative regulation of synaptic transmission	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0033864	positive regulation of NAD(P)H oxidase activity	ISO	J:155856
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:72247