GO Annotations Graph

• Symbol: Lrp2
• Name: low density lipoprotein receptor-related protein 2
• ID: MGI:95794

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:164563
Molecular Function	GO:0030492	hemoglobin binding	ISO	J:155856
Molecular Function	GO:0042562	hormone binding	ISO	J:155856
Molecular Function	GO:0042562	hormone binding	IBA	J:265628
Molecular Function	GO:0031994	insulin-like growth factor I binding	ISO	J:155856
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:113901
Molecular Function	GO:0005515	protein binding	IPI	J:133662
Molecular Function	GO:0005515	protein binding	IPI	J:296099
Molecular Function	GO:0005515	protein binding	IPI	J:95319
Molecular Function	GO:0005515	protein binding	IPI	J:171318
Molecular Function	GO:0005515	protein binding	IPI	J:273590
Molecular Function	GO:0005515	protein binding	IPI	J:82078
Molecular Function	GO:0005515	protein binding	IPI	J:104065
Molecular Function	GO:0005515	protein binding	IPI	J:149003
Molecular Function	GO:0140318	protein transporter activity	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Molecular Function	GO:0038023	signaling receptor activity	ISS	J:53162
Cellular Component	GO:0045177	apical part of cell	IDA	J:98337
Cellular Component	GO:0045177	apical part of cell	IDA	J:98256
Cellular Component	GO:0045177	apical part of cell	IDA	J:215153
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:178554
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:98256
Cellular Component	GO:0030424	axon	IDA	J:171318
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005903	brush border	ISO	J:155856
Cellular Component	GO:0005903	brush border	IDA	J:84433
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	IDA	J:60362
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:98256
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:171318
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:98256
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:98256
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:98256
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:98256
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005768	endosome	IDA	J:84433
Cellular Component	GO:0005768	endosome	IDA	J:67664
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:115189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:243398
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:98256
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:90197
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0097242	amyloid-beta clearance	ISO	J:155856
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0008283	cell population proliferation	IMP	J:95319
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:155856
Biological Process	GO:0061642	chemoattraction of axon	ISO	J:155856
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:231312
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0034311	diol metabolic process	IMP	J:53162
Biological Process	GO:0020028	endocytic hemoglobin import into cell	ISO	J:155856
Biological Process	GO:0006897	endocytosis	ISO	J:155856
Biological Process	GO:0016197	endosomal transport	ISO	J:155856
Biological Process	GO:1904447	folate import across plasma membrane	IMP	J:214694
Biological Process	GO:0030900	forebrain development	IMP	J:95319
Biological Process	GO:0007507	heart development	IMP	J:222159
Biological Process	GO:0046879	hormone secretion	ISO	J:155856
Biological Process	GO:0001822	kidney development	IMP	J:231949
Biological Process	GO:0008584	male gonad development	IMP	J:115189
Biological Process	GO:0030001	metal ion transport	ISO	J:155856
Biological Process	GO:0030001	metal ion transport	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:243398
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001843	neural tube closure	IMP	J:214694
Biological Process	GO:0140058	neuron projection arborization	IMP	J:171318
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:231312
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:155856
Biological Process	GO:0140077	positive regulation of lipoprotein transport	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:243398
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	IMP	J:183783
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0017038	protein import	ISO	J:155856
Biological Process	GO:0015031	protein transport	ISO	J:164563
Biological Process	GO:0015031	protein transport	IDA	J:140921
Biological Process	GO:0061156	pulmonary artery morphogenesis	IMP	J:231312
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:133662
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:121774
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:243418
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:243406
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:95319
Biological Process	GO:0006898	receptor-mediated endocytosis	IBA	J:265628
Biological Process	GO:0006898	receptor-mediated endocytosis	IMP	J:53162
Biological Process	GO:0044321	response to leptin	ISO	J:155856
Biological Process	GO:0044321	response to leptin	IDA	J:140921
Biological Process	GO:0044321	response to leptin	ISO	J:164563
Biological Process	GO:0010165	response to X-ray	ISO	J:155856
Biological Process	GO:0003139	secondary heart field specification	IMP	J:231312
Biological Process	GO:0007605	sensory perception of sound	IMP	J:134797
Biological Process	GO:0045056	transcytosis	ISO	J:155856
Biological Process	GO:0060068	vagina development	IMP	J:115189
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	IMP	J:231312
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159
Biological Process	GO:0042359	vitamin D metabolic process	IMP	J:53162