GO Annotations Graph

• Symbol: Gsr
• Name: glutathione reductase
• ID: MGI:95804

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0043295	glutathione binding	ISO	J:155856
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	ISO	J:155856
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IBA	J:265628
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IDA	J:5817
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IDA	J:6674
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IDA	J:35956
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IDA	J:10432
Molecular Function	GO:0004362	glutathione-disulfide reductase (NADPH) activity	IDA	J:5946
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:202604
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0098869	cellular oxidant detoxification	IDA	J:5817
Biological Process	GO:0034599	cellular response to oxidative stress	IBA	J:265628
Biological Process	GO:0006749	glutathione metabolic process	ISO	J:155856
Biological Process	GO:0006749	glutathione metabolic process	IBA	J:265628
Biological Process	GO:0006749	glutathione metabolic process	IC	J:5817
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856