GO Annotations Graph

• Symbol: Grin2a
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
• ID: MGI:95820

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	IMP	J:86846
Molecular Function	GO:0005262	calcium channel activity	IMP	J:78374
Molecular Function	GO:0005262	calcium channel activity	IGI	J:17924
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0005234	extracellularly glutamate-gated ion channel activity	ISO	J:155856
Molecular Function	GO:0016595	glutamate binding	ISO	J:155856
Molecular Function	GO:0035254	glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity	ISO	J:164563
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	IMP	J:34076
Molecular Function	GO:0005261	monoatomic cation channel activity	IMP	J:103735
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0042165	neurotransmitter binding	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:46495
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:20537
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:109557
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:103735
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:22295
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:34076
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:17924
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IGI	J:1333
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:110920
Molecular Function	GO:0005515	protein binding	IPI	J:286227
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:119798
Molecular Function	GO:0005515	protein binding	IPI	J:146779
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:145953
Molecular Function	GO:0005515	protein binding	IPI	J:312331
Molecular Function	GO:0005515	protein binding	IPI	J:241916
Molecular Function	GO:0005515	protein binding	IPI	J:116426
Molecular Function	GO:0005515	protein binding	IPI	J:227842
Molecular Function	GO:0005515	protein binding	IPI	J:106962
Molecular Function	GO:0005515	protein binding	IPI	J:145582
Molecular Function	GO:0005515	protein binding	IPI	J:86846
Molecular Function	GO:0005515	protein binding	IPI	J:37859
Molecular Function	GO:0005515	protein binding	IPI	J:298978
Molecular Function	GO:0005515	protein binding	IPI	J:95556
Molecular Function	GO:0005515	protein binding	IPI	J:48437
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IDA	J:227842
Cellular Component	GO:0009986	cell surface	IDA	J:128028
Cellular Component	GO:0009986	cell surface	IMP	J:128028
Cellular Component	GO:0009986	cell surface	IDA	J:301846
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:101619
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:111556
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:152455
Cellular Component	GO:0016020	membrane	IDA	J:169741
Cellular Component	GO:0016020	membrane	IDA	J:37859
Cellular Component	GO:0016020	membrane	IDA	J:34361
Cellular Component	GO:0043005	neuron projection	IMP	J:173402
Cellular Component	GO:0043005	neuron projection	IMP	J:175650
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:173402
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:164563
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IBA	J:265628
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IPI	J:20537
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IPI	J:37859
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9006510
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098794	postsynapse	IDA	J:298978
Cellular Component	GO:0014069	postsynaptic density	IDA	J:175650
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:227842
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:152455
Cellular Component	GO:0045211	postsynaptic membrane	NAS	J:92648
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:83403
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:84686
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:80744
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:114728
Cellular Component	GO:0045202	synapse	IDA	J:86846
Cellular Component	GO:0045202	synapse	IDA	J:119025
Cellular Component	GO:0045202	synapse	IDA	J:298978
Cellular Component	GO:0045202	synapse	IDA	J:86623
Cellular Component	GO:0097060	synaptic membrane	IDA	J:227842
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:160616
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0001508	action potential	ISO	J:155856
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:78374
Biological Process	GO:0006816	calcium ion transport	IMP	J:101085
Biological Process	GO:0006816	calcium ion transport	IGI	J:17924
Biological Process	GO:0006816	calcium ion transport	IMP	J:86846
Biological Process	GO:0071230	cellular response to amino acid stimulus	ISO	J:155856
Biological Process	GO:0071294	cellular response to zinc ion	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:41902
Biological Process	GO:0097061	dendritic spine organization	ISO	J:155856
Biological Process	GO:0033058	directional locomotion	IGI	J:66455
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:78374
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0060079	excitatory postsynaptic potential	IBA	J:265628
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:66455
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:66455
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:85901
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:86846
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:41902
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:34076
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:101085
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:114728
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007612	learning	IMP	J:103735
Biological Process	GO:0007612	learning	IMP	J:78374
Biological Process	GO:0007611	learning or memory	IMP	J:101085
Biological Process	GO:0007611	learning or memory	IMP	J:49227
Biological Process	GO:0040011	locomotion	IMP	J:89820
Biological Process	GO:0040011	locomotion	IMP	J:78374
Biological Process	GO:0007626	locomotory behavior	TAS	J:113959
Biological Process	GO:0060291	long-term synaptic potentiation	IBA	J:265628
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:163089
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:129729
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:163089
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:163089
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0007613	memory	IMP	J:45446
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:113959
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0042177	negative regulation of protein catabolic process	IGI	J:92648
Biological Process	GO:0022008	neurogenesis	IMP	J:102617
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:125170
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:125170
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	IGI	J:92648
Biological Process	GO:1903539	protein localization to postsynaptic membrane	IMP	J:92648
Biological Process	GO:1903539	protein localization to postsynaptic membrane	IGI	J:92648
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:22295
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:49227
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	NAS	J:88689
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IMP	J:114728
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:113959
Biological Process	GO:0001975	response to amphetamine	IMP	J:112494
Biological Process	GO:0045471	response to ethanol	ISO	J:164563
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0045471	response to ethanol	IMP	J:85901
Biological Process	GO:0009611	response to wounding	IMP	J:51277
Biological Process	GO:0009611	response to wounding	IGI	J:46495
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:89820
Biological Process	GO:0048511	rhythmic process	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	IMP	J:60443
Biological Process	GO:0019233	sensory perception of pain	IMP	J:119596
Biological Process	GO:0042428	serotonin metabolic process	IMP	J:78374
Biological Process	GO:0030431	sleep	IMP	J:109557
Biological Process	GO:0001964	startle response	IMP	J:89405
Biological Process	GO:0001964	startle response	IGI	J:101790
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0008542	visual learning	IMP	J:22295