GO Annotations Graph

• Symbol: Grin2d
• Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
• ID: MGI:95823

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016595	glutamate binding	ISO	J:155856
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity	ISO	J:164563
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0042165	neurotransmitter binding	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IDA	J:3203
Molecular Function	GO:0004972	NMDA glutamate receptor activity	IMP	J:84361
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:164563
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	NAS	J:92648
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:28825
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:28825
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	ISO	J:164563
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	IBA	J:265628
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	NAS	J:88689
Biological Process	GO:0051930	regulation of sensory perception of pain	IMP	J:119596
Biological Process	GO:0001964	startle response	IMP	J:89405
Biological Process	GO:0001964	startle response	IMP	J:58249
Biological Process	GO:0035249	synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IBA	J:265628