GO Annotations Graph

• Symbol: Grn
• Name: granulin
• ID: MGI:95832

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:227553
Molecular Function	GO:0005515	protein binding	IPI	J:269644
Molecular Function	GO:0005515	protein binding	IPI	J:227553
Molecular Function	GO:0005515	protein binding	IPI	J:269546
Molecular Function	GO:0005515	protein binding	IPI	J:121129
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IMP	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	IDA	J:261277
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:269546
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IDA	J:250451
Cellular Component	GO:0005576	extracellular region	IDA	J:242512
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:240061
Cellular Component	GO:0005615	extracellular space	IDA	J:100669
Cellular Component	GO:0005615	extracellular space	IDA	J:100669
Cellular Component	GO:0005615	extracellular space	IDA	J:100669
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:269546
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:269546
Cellular Component	GO:0005764	lysosome	IDA	J:242512
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:269546
Cellular Component	GO:0031982	vesicle	IDA	J:243041
Biological Process	GO:0002265	astrocyte activation involved in immune response	IMP	J:156824
Biological Process	GO:0001835	blastocyst hatching	IDA	J:100669
Biological Process	GO:0035988	chondrocyte proliferation	ISO	J:155856
Biological Process	GO:0007566	embryo implantation	IDA	J:100669
Biological Process	GO:0050673	epithelial cell proliferation	IDA	J:100669
Biological Process	GO:0035641	locomotory exploration behavior	IMP	J:250046
Biological Process	GO:0007042	lysosomal lumen acidification	ISO	J:164563
Biological Process	GO:1905146	lysosomal protein catabolic process	IMP	J:250046
Biological Process	GO:0007041	lysosomal transport	IMP	J:250451
Biological Process	GO:0007041	lysosomal transport	ISO	J:164563
Biological Process	GO:0007040	lysosome organization	IMP	J:269546
Biological Process	GO:0099558	maintenance of synapse structure	IMP	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0099558	maintenance of synapse structure	IDA	J:261277
Biological Process	GO:0060179	male mating behavior	ISO	J:155856
Biological Process	GO:0002282	microglial cell activation involved in immune response	IMP	J:156824
Biological Process	GO:0051346	negative regulation of hydrolase activity	IMP	J:250046
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:156824
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:156824
Biological Process	GO:1903979	negative regulation of microglial cell activation	IMP	J:188324
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:1902564	negative regulation of neutrophil activation	ISO	J:164563
Biological Process	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	ISO	J:164563
Biological Process	GO:0061351	neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	IDA	J:269542
Biological Process	GO:1905247	positive regulation of aspartic-type peptidase activity	ISO	J:164563
Biological Process	GO:1905247	positive regulation of aspartic-type peptidase activity	IMP	J:243041
Biological Process	GO:0048680	positive regulation of axon regeneration	IMP	J:243041
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:269542
Biological Process	GO:1900426	positive regulation of defense response to bacterium	IMP	J:156824
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IDA	J:269542
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IDA	J:100669
Biological Process	GO:0106016	positive regulation of inflammatory response to wounding	IDA	J:269542
Biological Process	GO:1905673	positive regulation of lysosome organization	IDA	J:242512
Biological Process	GO:1905673	positive regulation of lysosome organization	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IMP	J:188324
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:1903334	positive regulation of protein folding	IMP	J:269546
Biological Process	GO:1904075	positive regulation of trophectodermal cell proliferation	IDA	J:100669
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:1905671	regulation of lysosome organization	IMP	J:250046
Biological Process	GO:0032355	response to estradiol	ISO	J:155856
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:250046
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0001834	trophectodermal cell proliferation	IDA	J:100669