GO Annotations Graph

• Symbol: Gsn
• Name: gelsolin
• ID: MGI:95851

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0045159	myosin II binding	ISO	J:164563
Molecular Function	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding	IPI	J:292538
Molecular Function	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Cellular Component	GO:0030478	actin cap	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IDA	J:219057
Cellular Component	GO:0030027	lamellipodium	IDA	J:91946
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:143718
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0002102	podosome	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0016528	sarcoplasm	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:292538
Biological Process	GO:0051693	actin filament capping	ISO	J:164563
Biological Process	GO:0051693	actin filament capping	IDA	J:219057
Biological Process	GO:0030042	actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030042	actin filament depolymerization	IMP	J:292538
Biological Process	GO:0030041	actin filament polymerization	IDA	J:219057
Biological Process	GO:0030041	actin filament polymerization	ISO	J:164563
Biological Process	GO:0090527	actin filament reorganization	ISO	J:164563
Biological Process	GO:0051014	actin filament severing	ISO	J:164563
Biological Process	GO:0051014	actin filament severing	ISO	J:155856
Biological Process	GO:0051014	actin filament severing	IMP	J:219057
Biological Process	GO:0051014	actin filament severing	IBA	J:265628
Biological Process	GO:0045010	actin nucleation	IEA	J:72247
Biological Process	GO:0008154	actin polymerization or depolymerization	ISO	J:155856
Biological Process	GO:0008154	actin polymerization or depolymerization	IBA	J:265628
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0051016	barbed-end actin filament capping	IBA	J:265628
Biological Process	GO:0086003	cardiac muscle cell contraction	IMP	J:292538
Biological Process	GO:0030031	cell projection assembly	IBA	J:265628
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:155856
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:143718
Biological Process	GO:0007417	central nervous system development	IBA	J:265628
Biological Process	GO:0060271	cilium assembly	ISO	J:164563
Biological Process	GO:0097284	hepatocyte apoptotic process	ISO	J:164563
Biological Process	GO:0046597	negative regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:219057
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:155856
Biological Process	GO:0051127	positive regulation of actin nucleation	ISO	J:164563
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1902174	positive regulation of keratinocyte apoptotic process	ISO	J:164563
Biological Process	GO:1903923	positive regulation of protein processing in phagocytic vesicle	IMP	J:219057
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0030155	regulation of cell adhesion	ISO	J:155856
Biological Process	GO:1903903	regulation of establishment of T cell polarity	ISO	J:164563
Biological Process	GO:1903906	regulation of plasma membrane raft polarization	ISO	J:164563
Biological Process	GO:0071801	regulation of podosome assembly	ISO	J:164563
Biological Process	GO:1903909	regulation of receptor clustering	ISO	J:164563
Biological Process	GO:0055119	relaxation of cardiac muscle	IMP	J:292538
Biological Process	GO:0097017	renal protein absorption	ISO	J:164563
Biological Process	GO:0035994	response to muscle stretch	IMP	J:292538
Biological Process	GO:0042989	sequestering of actin monomers	ISO	J:164563
Biological Process	GO:0014891	striated muscle atrophy	ISO	J:164563
Biological Process	GO:0016192	vesicle-mediated transport	IMP	J:86517