GO Annotations Graph

• Symbol: H2-Aa
• Name: histocompatibility 2, class II antigen A, alpha
• ID: MGI:95895

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0023026	MHC class II protein complex binding	IBA	J:265628
Molecular Function	GO:0042605	peptide antigen binding	IDA	J:88532
Molecular Function	GO:0042605	peptide antigen binding	IDA	J:65235
Molecular Function	GO:0005515	protein binding	IPI	J:88528
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:88532
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:68798
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:4119
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:85084
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31624
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31625
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:31786
Cellular Component	GO:0005764	lysosome	IDA	J:88531
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0042613	MHC class II protein complex	IBA	J:265628
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:68798
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:31786
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:88528
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:31786
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:85084
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:31625
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:31624
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:85084
Cellular Component	GO:0042613	MHC class II protein complex	IDA	J:4119
Cellular Component	GO:0005886	plasma membrane	IDA	J:88531
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0019882	antigen processing and presentation	IDA	J:88532
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA	J:265628
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:88533
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:4119
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:85084
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:88532
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:31624
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:31625
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:65235
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	J:72827
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	IDA	J:65235
Biological Process	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA	J:60000
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	IBA	J:265628
Biological Process	GO:0042130	negative regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	IBA	J:265628
Biological Process	GO:0050870	positive regulation of T cell activation	IBA	J:265628
Biological Process	GO:0045582	positive regulation of T cell differentiation	IDA	J:31625
Biological Process	GO:0034341	response to type II interferon	IDA	J:172894