GO Annotations Graph

• Symbol: H2-M2
• Name: histocompatibility 2, M region locus 2
• ID: MGI:95914

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:164563
Molecular Function	GO:0030881	beta-2-microglobulin binding	ISO	J:164563
Molecular Function	GO:0030881	beta-2-microglobulin binding	ISO	J:164563
Molecular Function	GO:0042610	CD8 receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042288	MHC class I protein binding	ISO	J:164563
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	ISO	J:164563
Molecular Function	GO:0042605	peptide antigen binding	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0042608	T cell receptor binding	ISO	J:164563
Molecular Function	GO:0046978	TAP1 binding	ISO	J:164563
Molecular Function	GO:0046979	TAP2 binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:89343
Cellular Component	GO:0033106	cis-Golgi network membrane	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0042612	MHC class I protein complex	ISO	J:164563
Cellular Component	GO:0042612	MHC class I protein complex	ISO	J:164563
Cellular Component	GO:0042612	MHC class I protein complex	ISO	J:164563
Cellular Component	GO:0032398	MHC class Ib protein complex	ISO	J:164563
Cellular Component	GO:0032398	MHC class Ib protein complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002486	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA	J:265628
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA	J:265628
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IBA	J:265628