GO Annotations Graph

• Symbol: Ptpn6
• Name: protein tyrosine phosphatase, non-receptor type 6
• ID: MGI:96055

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:231275
Molecular Function	GO:0005126	cytokine receptor binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046703	natural killer cell lectin-like receptor binding	ISO	J:155856
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IEA	J:60000
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	IBA	J:265628
Molecular Function	GO:0001784	phosphotyrosine residue binding	IPI	J:54974
Molecular Function	GO:0005515	protein binding	IPI	J:314642
Molecular Function	GO:0005515	protein binding	IPI	J:195394
Molecular Function	GO:0005515	protein binding	IPI	J:72778
Molecular Function	GO:0005515	protein binding	IPI	J:165472
Molecular Function	GO:0005515	protein binding	IPI	J:201266
Molecular Function	GO:0005515	protein binding	IPI	J:188566
Molecular Function	GO:0005515	protein binding	IPI	J:208171
Molecular Function	GO:0005515	protein binding	IPI	J:248464
Molecular Function	GO:0005515	protein binding	IPI	J:245336
Molecular Function	GO:0005515	protein binding	IPI	J:250441
Molecular Function	GO:0005515	protein binding	IPI	J:161854
Molecular Function	GO:0005515	protein binding	IPI	J:200343
Molecular Function	GO:0005515	protein binding	IPI	J:314643
Molecular Function	GO:0005515	protein binding	IPI	J:126125
Molecular Function	GO:0005515	protein binding	IPI	J:146296
Molecular Function	GO:0005515	protein binding	IPI	J:194234
Molecular Function	GO:0005515	protein binding	IPI	J:36542
Molecular Function	GO:0005515	protein binding	IPI	J:54975
Molecular Function	GO:0005515	protein binding	IPI	J:31423
Molecular Function	GO:0005515	protein binding	IPI	J:39072
Molecular Function	GO:0005515	protein binding	IPI	J:31423
Molecular Function	GO:0005515	protein binding	IPI	J:31423
Molecular Function	GO:0005515	protein binding	IPI	J:51814
Molecular Function	GO:0005515	protein binding	IPI	J:84951
Molecular Function	GO:0005515	protein binding	IPI	J:35279
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	IDA	J:242717
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:273610
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	TAS	Reactome:R-MMU-1169240
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	TAS	Reactome:R-MMU-877301
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:242717
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:58900
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:36542
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:35279
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:31423
Molecular Function	GO:0042169	SH2 domain binding	IDA	J:31423
Molecular Function	GO:0017124	SH3 domain binding	IDA	J:31423
Molecular Function	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	ISO	J:164563
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	IDA	J:35279
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:242717
Cellular Component	GO:0005737	cytoplasm	TAS	J:36542
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169240
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169250
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-548971
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-877301
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IMP	J:42368
Biological Process	GO:0050853	B cell receptor signaling pathway	IGI	J:194234
Biological Process	GO:0030154	cell differentiation	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	TAS	J:36542
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:1905867	epididymis development	IMP	J:67582
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:54974
Biological Process	GO:0000165	MAPK cascade	IMP	J:35279
Biological Process	GO:0000165	MAPK cascade	IMP	J:42368
Biological Process	GO:0035855	megakaryocyte development	IMP	J:197924
Biological Process	GO:0000278	mitotic cell cycle	IBA	J:265628
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:6485
Biological Process	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP	J:42368
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	IDA	J:242717
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IGI	J:126125
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:42368
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:35279
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:42368
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:35279
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	IDA	J:314643
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IMP	J:42368
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:35279
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:35279
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	IMP	J:35279
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:126125
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	IBA	J:265628
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:42368
Biological Process	GO:0070527	platelet aggregation	IMP	J:197924
Biological Process	GO:0030220	platelet formation	IGI	J:197924
Biological Process	GO:0030220	platelet formation	IGI	J:197924
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	IMP	J:197924
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	IDA	J:35279
Biological Process	GO:0006470	protein dephosphorylation	IDA	J:31423
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:35279
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:35279
Biological Process	GO:0045577	regulation of B cell differentiation	IMP	J:42368
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IGI	J:194234
Biological Process	GO:0042098	T cell proliferation	IMP	J:35279
Biological Process	GO:0042098	T cell proliferation	IMP	J:35279
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:35279